PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE

To provide compounds that induce proteolysis of Btk via a ubiquitin proteolysis pathway.SOLUTION: The present invention provides compounds of formula (I), where R1, R2, R3, R4A, R4b and R5 are as defined herein, and pharmaceutically acceptable salts thereof, which are useful as agents in treatment o...

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Hauptverfasser:	BERENGER BIANNIC, ELIZABETH L NOEY, JOSHUA N PAYETTE, OKANO AKINORI, SHAHAB MORTEZAEI, BIAN ZHIGUO, JASON P BURKE, ASHLEY M ADAMS, VENKAT REDDY MALI, ALEXEY A RIVKIN, ZHAO XIANRUI, MATTHEW H KATCHER, VIOLETA L MARIN, JIANG XINGYU, JIA ZHAOZHONG J, KEVIN R WOLLER, SPENCER O SHOLZ, JEFFERY A ZABLOCKI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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