CYCLIC PEPTIDES FOR PROTECTION AGAINST RESPIRATORY SYNCYTIAL VIRUS

To provide a cyclic peptide, a conjugate comprising the cyclic peptide and a lipopeptide building block, a bundle of the conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same.SOLUTION: A cyclic peptide comprises a...

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Hauptverfasser:	ARMANDO ZUNIGA, KERSTIN MOEHLE, ARIN GHASPARIAN, JOHN A ROBINSON, ANIEBRYS MARRERO NODARSE, OLIVER RASSEK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a cyclic peptide, a conjugate comprising the cyclic peptide and a lipopeptide building block, a bundle of the conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same.SOLUTION: A cyclic peptide comprises an amino acid sequence (I), where the amino acid sequence (I) comprises X1-X2-X3-C4-X5-X6-X7-C8-X9-X10-X11-P12-I13-T14-N15-D16-Q17-K18-K19-L20-C21-X22-X23-X24-C25-X26-X27-X28-X29-X30, where the cysteines C4 and C25 form a first disulfide bond and the cysteines C8 and C21 form a second disulfide bond.SELECTED DRAWING: None 【課題】環状ペプチド、かかる環状ペプチドおよびリポペプチドビルディングブロックを含むコンジュゲート、かかるコンジュゲートの束、コンジュゲートの少なくとも１つの束を含む合成ウイルス様粒子、およびそれを含む薬学的組成物を提供する。【解決手段】アミノ酸配列（Ｉ）を含む環状ペプチドであって、前記アミノ酸配列（Ｉ）が、Ｘ１－Ｘ２－Ｘ３－Ｃ４－Ｘ５－Ｘ６－Ｘ７－Ｃ８－Ｘ９－Ｘ１０－Ｘ１１－Ｐ１２－Ｉ１３－Ｔ１４－Ｎ１５－Ｄ１６－Ｑ１７－Ｋ１８－Ｋ１９－Ｌ２０－Ｃ２１－Ｘ２２－Ｘ２３－Ｘ２４－Ｃ２５－Ｘ２６－Ｘ２７－Ｘ２８－Ｘ２９－Ｘ３０を含み、システインＣ４およびＣ２５は第１のジスルフィド結合を形成し、システインＣ８およびＣ２１は第２のジスルフィド結合を形成する、環状ペプチドを提供する。【選択図】なし