PYRIDINE COMPOUND SUBSTITUTED WITH TRIAZOLE
To provide a compound which has an inhibitory effect on an enzyme that produces 20-HETE, and an agent for preventing or mitigating polycystic kidney containing the compound as an active ingredient.SOLUTION: The present invention provides a compound represented by formula [I], or a pharmaceutically a...
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| creator | KAWAMURA MADOKA TANAKA HIROAKI FUNAYAMA KOSUKE SUZUKI KAZUAKI |
| description | To provide a compound which has an inhibitory effect on an enzyme that produces 20-HETE, and an agent for preventing or mitigating polycystic kidney containing the compound as an active ingredient.SOLUTION: The present invention provides a compound represented by formula [I], or a pharmaceutically acceptable salt thereof. [In the formula, each of R1 to R4 independently represents H, F, methyl, or the like; X represents -O-, -S-, or -CH2-; and R5 represents a substituent such as 2-methyl-heptoxypropanoate, 4-methoxypyridin-2-carboxylate-6-butyl, or 2-methyl-3,4-dihydrochromene-2-carboxylate-7-methyl.]SELECTED DRAWING: None
【課題】２０－ＨＥＴＥを産生する酵素を阻害する作用を有する化合物、及び前記化合物を有効成分として含有する多発性嚢胞腎の予防又は改善剤の提供。【解決手段】式［Ｉ］で表される化合物又はその製薬学的に許容される塩。JPEG2022053556000171.jpg2852［Ｒ１～Ｒ４は、各々独立して、Ｈ、Ｆ、メチル等；Ｘは、－Ｏ－、－Ｓ－、又は－ＣＨ２－；Ｒ５は、例えば、２－メチル－ヘプトキシプロパン酸、４－メトキシピリジン－２－カルボン酸－６－ブチル、２－メチル－３，４－ジヒドロクロメン－２－カルボン酸－７－メチル等の置換基］【選択図】なし |
| format | Patent |
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【課題】２０－ＨＥＴＥを産生する酵素を阻害する作用を有する化合物、及び前記化合物を有効成分として含有する多発性嚢胞腎の予防又は改善剤の提供。【解決手段】式［Ｉ］で表される化合物又はその製薬学的に許容される塩。JPEG2022053556000171.jpg2852［Ｒ１～Ｒ４は、各々独立して、Ｈ、Ｆ、メチル等；Ｘは、－Ｏ－、－Ｓ－、又は－ＣＨ２－；Ｒ５は、例えば、２－メチル－ヘプトキシプロパン酸、４－メトキシピリジン－２－カルボン酸－６－ブチル、２－メチル－３，４－ジヒドロクロメン－２－カルボン酸－７－メチル等の置換基］【選択図】なし</description><language>eng ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220406&DB=EPODOC&CC=JP&NR=2022053556A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220406&DB=EPODOC&CC=JP&NR=2022053556A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAWAMURA MADOKA</creatorcontrib><creatorcontrib>TANAKA HIROAKI</creatorcontrib><creatorcontrib>FUNAYAMA KOSUKE</creatorcontrib><creatorcontrib>SUZUKI KAZUAKI</creatorcontrib><title>PYRIDINE COMPOUND SUBSTITUTED WITH TRIAZOLE</title><description>To provide a compound which has an inhibitory effect on an enzyme that produces 20-HETE, and an agent for preventing or mitigating polycystic kidney containing the compound as an active ingredient.SOLUTION: The present invention provides a compound represented by formula [I], or a pharmaceutically acceptable salt thereof. [In the formula, each of R1 to R4 independently represents H, F, methyl, or the like; X represents -O-, -S-, or -CH2-; and R5 represents a substituent such as 2-methyl-heptoxypropanoate, 4-methoxypyridin-2-carboxylate-6-butyl, or 2-methyl-3,4-dihydrochromene-2-carboxylate-7-methyl.]SELECTED DRAWING: None
【課題】２０－ＨＥＴＥを産生する酵素を阻害する作用を有する化合物、及び前記化合物を有効成分として含有する多発性嚢胞腎の予防又は改善剤の提供。【解決手段】式［Ｉ］で表される化合物又はその製薬学的に許容される塩。JPEG2022053556000171.jpg2852［Ｒ１～Ｒ４は、各々独立して、Ｈ、Ｆ、メチル等；Ｘは、－Ｏ－、－Ｓ－、又は－ＣＨ２－；Ｒ５は、例えば、２－メチル－ヘプトキシプロパン酸、４－メトキシピリジン－２－カルボン酸－６－ブチル、２－メチル－３，４－ジヒドロクロメン－２－カルボン酸－７－メチル等の置換基］【選択図】なし</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAOiAzydPH0c1Vw9vcN8A_1c1EIDnUKDvEMCQ1xdVEI9wzxUAgJ8nSM8vdx5WFgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGRgamxqamZo7GRCkCAPLKJdE</recordid><startdate>20220406</startdate><enddate>20220406</enddate><creator>KAWAMURA MADOKA</creator><creator>TANAKA HIROAKI</creator><creator>FUNAYAMA KOSUKE</creator><creator>SUZUKI KAZUAKI</creator><scope>EVB</scope></search><sort><creationdate>20220406</creationdate><title>PYRIDINE COMPOUND SUBSTITUTED WITH TRIAZOLE</title><author>KAWAMURA MADOKA ; TANAKA HIROAKI ; FUNAYAMA KOSUKE ; SUZUKI KAZUAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2022053556A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KAWAMURA MADOKA</creatorcontrib><creatorcontrib>TANAKA HIROAKI</creatorcontrib><creatorcontrib>FUNAYAMA KOSUKE</creatorcontrib><creatorcontrib>SUZUKI KAZUAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAWAMURA MADOKA</au><au>TANAKA HIROAKI</au><au>FUNAYAMA KOSUKE</au><au>SUZUKI KAZUAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIDINE COMPOUND SUBSTITUTED WITH TRIAZOLE</title><date>2022-04-06</date><risdate>2022</risdate><abstract>To provide a compound which has an inhibitory effect on an enzyme that produces 20-HETE, and an agent for preventing or mitigating polycystic kidney containing the compound as an active ingredient.SOLUTION: The present invention provides a compound represented by formula [I], or a pharmaceutically acceptable salt thereof. [In the formula, each of R1 to R4 independently represents H, F, methyl, or the like; X represents -O-, -S-, or -CH2-; and R5 represents a substituent such as 2-methyl-heptoxypropanoate, 4-methoxypyridin-2-carboxylate-6-butyl, or 2-methyl-3,4-dihydrochromene-2-carboxylate-7-methyl.]SELECTED DRAWING: None
【課題】２０－ＨＥＴＥを産生する酵素を阻害する作用を有する化合物、及び前記化合物を有効成分として含有する多発性嚢胞腎の予防又は改善剤の提供。【解決手段】式［Ｉ］で表される化合物又はその製薬学的に許容される塩。JPEG2022053556000171.jpg2852［Ｒ１～Ｒ４は、各々独立して、Ｈ、Ｆ、メチル等；Ｘは、－Ｏ－、－Ｓ－、又は－ＣＨ２－；Ｒ５は、例えば、２－メチル－ヘプトキシプロパン酸、４－メトキシピリジン－２－カルボン酸－６－ブチル、２－メチル－３，４－ジヒドロクロメン－２－カルボン酸－７－メチル等の置換基］【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| title | PYRIDINE COMPOUND SUBSTITUTED WITH TRIAZOLE |
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