COMPOSITION FOR PROMOTING PERCUTANEOUS ABSORPTION OF HUMECTANT

To provide a method for percutaneous absorption of a hydrophilic drug by using a low molecular gelling agent in order to improve not only a use feeling but also percutaneous absorption properties.SOLUTION: A method for percutaneous absorption of a hydrophilic drug is characterized by using a lipid peptide compound consisting of at least one of a compound represented by the formula (1) and an analogous compound thereof or a pharmaceutically usable salt thereof (in the formula, R1 represents an aliphatic group having 9 to 23 carbon atoms, R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, R3 represents a -(CH2)n-X group, n represents a numeral number of 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a fused heterocycle comprising a 5- or 6-membered ring or 5- and 6-membered rings which may have 1 to 3 nitrogen atoms).SELECTED DRAWING: None 【課題】低分子ゲル化剤を用い、使用感のみならず経皮吸収性の向上を図った親水性薬物を経皮吸収させる方法を提供すること。【解決手段】下記式（１）で表される化合物並びにその類似化合物又はその薬学的に使用可能な塩のうちの少なくとも一種からなる脂質ペプチド型化合物を用いることを特徴とする、親水性薬物を経皮吸収させる方法。【化１】（式中、Ｒ１は炭素原子数９乃至２３の脂肪族基を表し、Ｒ２は水素原子、又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基を表し、Ｒ３は−（ＣＨ２）ｎ−Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、−ＣＯＮＨ２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）【選択図】なし