PERSONALIZED IMMUNOTHERAPY AGAINST SEVERAL NEURONAL AND BRAIN TUMORS

To provide peptides for use in cancer immunotherapy.SOLUTION: Provided are a peptide comprising an amino acid sequence selected from the group of 106 particular amino acid sequences, each of which has a different sequence, and variant sequences thereof which are at least 90% homologous to the partic...

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Bibliographische Detailangaben
Hauptverfasser:	JENS FRITSCHE, COLETTE SONG, STEFFAN WALTER, HILF NORBERT, WEINSCHENK TONI, OLIVER SCHORR, HARPREET SINGH, SABRINA KUTTRUFF-COQUI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide peptides for use in cancer immunotherapy.SOLUTION: Provided are a peptide comprising an amino acid sequence selected from the group of 106 particular amino acid sequences, each of which has a different sequence, and variant sequences thereof which are at least 90% homologous to the particular 106 amino acid sequences, and pharmacologically acceptable salts thereof, the variant inducing cross-reaction between T cells and the variant peptide, and the peptide being not a full-length polypeptide.SELECTED DRAWING: None 【課題】がんの免疫療法で使用するためのペプチドの提供。【解決手段】それぞれ配列の異なる、特定の106種のアミノ酸配列の群から選択されるアミノ酸配列を含んでなるペプチド、および前記特定の106種のアミノ酸配列と少なくとも９０％相同的なそれらの変異配列および薬学的に許容可能な（ｐｈａｒｍａｃｅｕｔｉｃａｌａｃｃｅｐｔａｂｌｅ）それらの塩であって、前記変異体がＴ細胞と前記変異体ペプチドとの交差反応を誘発し、前記ペプチドが完全長ポリペプチドでない、ペプチド。【選択図】なし