CROSS REACTIVE ANTIBODIES BINDING TO HUMAN AND RAT RENAL EPITHELIAL PODOPLANINS, AND VARIABLE REGION FRAGMENT THEREOF

To provide antibodies and small molecule antibodies that have cross reactivity that can target both rat and human renal epithelial podoplanins.SOLUTION: Provided is a cross reactive antibody binding to human and rat renal epithelial podoplanins, or a cross reactive antibody variable region fragment, having at least one of the following six CDR amino acid sequences, or having at least one amino acid sequence comprising addition, substitution, or deletion of one to some amino acids in the following six CDR amino acid sequences, or having at least one amino acid sequence having 80% or more identity with the following six CDR amino acid sequences: heavy chain CDR1: DYGVN (SEQ ID NO: 1); heavy chain CDR2: VIWGGGNTYYNSALKS (SEQ ID NO: 2); heavy chain CDR3: HRGA (SEQ ID NO: 3); light chain CDR1: KSSQSLLNSGNQKNYLI (SEQ ID NO: 4); light chain CDR2: WASTRES (SEQ ID NO: 5); and light chain CDR3: QNDHTYPLT (SEQ ID NO: 6).SELECTED DRAWING: None 【課題】ラットとヒトの腎上皮ポドプラニンの両方を標的とできる標的交差性を持つ抗体や低分子抗体を提供すること。【解決手段】以下の６つのＣＤＲのアミノ酸配列を少なくとも１つ有するか、以下の６つのＣＤＲのアミノ酸配列において１から数個のアミノ酸の付加、置換、若しくは欠失を含むアミノ酸配列を少なくとも１つ有するか、以下の６つのＣＤＲのアミノ酸配列と８０％以上の同一性を有するアミノ酸配列を少なくとも１つ有する、ヒトとラットの腎上皮ポドプラニンに結合する交差性抗体又は交差性抗体可変領域断片：重鎖ＣＤＲ１：DYGVN（配列番号：１）重鎖ＣＤＲ２：VIWGGGNTYYNSALKS（配列番号：２）重鎖ＣＤＲ３：HRGA（配列番号：３）軽鎖ＣＤＲ１：KSSQSLLNSGNQKNYLI（配列番号：４）軽鎖ＣＤＲ２：WASTRES（配列番号：５）軽鎖ＣＤＲ３：QNDHTYPLT（配列番号：６）。【選択図】なし