pH-SENSITIVE LIPOSOME
To provide a pH-sensitive liposome which can shift a zeta potential thereof from positive to negative under an arbitrary pH condition in a predetermined range by adjusting a content ratio of a specific component which constitutes the liposome.SOLUTION: The pH-sensitive liposome comprises, as membran...
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| creator | NABA YOSHIHIKO |
| description | To provide a pH-sensitive liposome which can shift a zeta potential thereof from positive to negative under an arbitrary pH condition in a predetermined range by adjusting a content ratio of a specific component which constitutes the liposome.SOLUTION: The pH-sensitive liposome comprises, as membrane components, a phospholipid, steroids, anionic substance, and an amphoteric substance, where contents of the anionic substance and the amphoteric substance relative to whole membrane components are 0-20 mass% and 5-20 mass%, respectively. And, when dispersed in an aqueous medium of the following respective pH conditions, the zeta-potential is negative at pH 5 or lower and is negative at pH 8 or more, and shifts from positive to negative in a pH range of 5-8.SELECTED DRAWING: None
【課題】リポソームを構成する特定の構成成分の含有比率を調整することで、所定の範囲内における任意のｐＨ条件下でリポソームのゼータ電位をプラスからマイナスへ移行させることのできるｐＨ感受性リポソームを提供する。【解決手段】リン脂質と、ステロイド類と、アニオン性物質と、両イオン性物質とを、膜構成成分として含み、膜構成成分全体に対して、アニオン性物質を０〜２０質量％、及び前記両イオン性物質を５〜２０質量％含むことを特徴とする。そして、以下の各ｐＨ条件の水性媒体中に分散させたとき、リポソームのゼータ電位が、ｐＨ５以下でプラスであり、ｐＨ８以上でマイナスであり、そして、ｐＨ５〜８の間で、ｐＨ値の増加とともにプラスからマイナスへ移行するようにした。【選択図】なし |
| format | Patent |
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【課題】リポソームを構成する特定の構成成分の含有比率を調整することで、所定の範囲内における任意のｐＨ条件下でリポソームのゼータ電位をプラスからマイナスへ移行させることのできるｐＨ感受性リポソームを提供する。【解決手段】リン脂質と、ステロイド類と、アニオン性物質と、両イオン性物質とを、膜構成成分として含み、膜構成成分全体に対して、アニオン性物質を０〜２０質量％、及び前記両イオン性物質を５〜２０質量％含むことを特徴とする。そして、以下の各ｐＨ条件の水性媒体中に分散させたとき、リポソームのゼータ電位が、ｐＨ５以下でプラスであり、ｐＨ８以上でマイナスであり、そして、ｐＨ５〜８の間で、ｐＨ値の増加とともにプラスからマイナスへ移行するようにした。【選択図】なし</description><language>eng ; jpn</language><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190322&DB=EPODOC&CC=JP&NR=2019042679A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190322&DB=EPODOC&CC=JP&NR=2019042679A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NABA YOSHIHIKO</creatorcontrib><title>pH-SENSITIVE LIPOSOME</title><description>To provide a pH-sensitive liposome which can shift a zeta potential thereof from positive to negative under an arbitrary pH condition in a predetermined range by adjusting a content ratio of a specific component which constitutes the liposome.SOLUTION: The pH-sensitive liposome comprises, as membrane components, a phospholipid, steroids, anionic substance, and an amphoteric substance, where contents of the anionic substance and the amphoteric substance relative to whole membrane components are 0-20 mass% and 5-20 mass%, respectively. And, when dispersed in an aqueous medium of the following respective pH conditions, the zeta-potential is negative at pH 5 or lower and is negative at pH 8 or more, and shifts from positive to negative in a pH range of 5-8.SELECTED DRAWING: None
【課題】リポソームを構成する特定の構成成分の含有比率を調整することで、所定の範囲内における任意のｐＨ条件下でリポソームのゼータ電位をプラスからマイナスへ移行させることのできるｐＨ感受性リポソームを提供する。【解決手段】リン脂質と、ステロイド類と、アニオン性物質と、両イオン性物質とを、膜構成成分として含み、膜構成成分全体に対して、アニオン性物質を０〜２０質量％、及び前記両イオン性物質を５〜２０質量％含むことを特徴とする。そして、以下の各ｐＨ条件の水性媒体中に分散させたとき、リポソームのゼータ電位が、ｐＨ５以下でプラスであり、ｐＨ８以上でマイナスであり、そして、ｐＨ５〜８の間で、ｐＨ値の増加とともにプラスからマイナスへ移行するようにした。【選択図】なし</description><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAt8NANdvUL9gzxDHNV8PEM8A_293XlYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBoaWBiZGZuaWjsZEKQIA8VUfpw</recordid><startdate>20190322</startdate><enddate>20190322</enddate><creator>NABA YOSHIHIKO</creator><scope>EVB</scope></search><sort><creationdate>20190322</creationdate><title>pH-SENSITIVE LIPOSOME</title><author>NABA YOSHIHIKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2019042679A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2019</creationdate><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>NABA YOSHIHIKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NABA YOSHIHIKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>pH-SENSITIVE LIPOSOME</title><date>2019-03-22</date><risdate>2019</risdate><abstract>To provide a pH-sensitive liposome which can shift a zeta potential thereof from positive to negative under an arbitrary pH condition in a predetermined range by adjusting a content ratio of a specific component which constitutes the liposome.SOLUTION: The pH-sensitive liposome comprises, as membrane components, a phospholipid, steroids, anionic substance, and an amphoteric substance, where contents of the anionic substance and the amphoteric substance relative to whole membrane components are 0-20 mass% and 5-20 mass%, respectively. And, when dispersed in an aqueous medium of the following respective pH conditions, the zeta-potential is negative at pH 5 or lower and is negative at pH 8 or more, and shifts from positive to negative in a pH range of 5-8.SELECTED DRAWING: None
【課題】リポソームを構成する特定の構成成分の含有比率を調整することで、所定の範囲内における任意のｐＨ条件下でリポソームのゼータ電位をプラスからマイナスへ移行させることのできるｐＨ感受性リポソームを提供する。【解決手段】リン脂質と、ステロイド類と、アニオン性物質と、両イオン性物質とを、膜構成成分として含み、膜構成成分全体に対して、アニオン性物質を０〜２０質量％、及び前記両イオン性物質を５〜２０質量％含むことを特徴とする。そして、以下の各ｐＨ条件の水性媒体中に分散させたとき、リポソームのゼータ電位が、ｐＨ５以下でプラスであり、ｐＨ８以上でマイナスであり、そして、ｐＨ５〜８の間で、ｐＨ値の増加とともにプラスからマイナスへ移行するようにした。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING |
| title | pH-SENSITIVE LIPOSOME |
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