EZETIMIBE-CONTAINING TABLET THAT COMPRISES ADEQUATE AMOUNT OF VINYLPYRROLIDONE POLYMER
PROBLEM TO BE SOLVED: To provide useful technical means for producing an ezetimibe-containing tablet having chemically stable improving effect of ezetimibe and highly suppressing effect of tablet coloring, when stored under harsh storage conditions.SOLUTION: A tablet (preferably free of crospovidone...
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| creator | TANAKA YUMA UKAI MASARU |
| description | PROBLEM TO BE SOLVED: To provide useful technical means for producing an ezetimibe-containing tablet having chemically stable improving effect of ezetimibe and highly suppressing effect of tablet coloring, when stored under harsh storage conditions.SOLUTION: A tablet (preferably free of crospovidone) that comprises ezetimibe and a polymer of 1-vinyl 2-pyrrolidone, such as 0.1 to 2.8% by weight of povidone with respect to the total amount of an uncoated tablet, is produced. Preferably the tablet contains a granule containing ezetimibe, and the granule is capable of producing by methods, such as stirring granulation, fluid layer granulation, and spray drying granulation.SELECTED DRAWING: None
【課題】本発明は、苛酷な保存条件下で保存した場合における、エゼチミブの化学的な安定性の高い改善効果と錠剤着色の高い抑制効果をもつ、エゼチミブを含有する錠剤を製造するための有用な技術的手段を提供すること。【解決手段】エゼチミブ、及び素錠の全重量に対して０．１〜２．８重量％のポビドン等の１−ビニル-２−ピロリドンの重合体、を含む錠剤（好ましくはクロスポビドンを含まない。）を製造する。其の錠剤はエゼチミブを含む造粒物を含有することが望ましく、其の造粒物は攪拌造粒や流動層造粒、噴霧乾燥造粒等の方法によって製造することが可能である。【選択図】なし |
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【課題】本発明は、苛酷な保存条件下で保存した場合における、エゼチミブの化学的な安定性の高い改善効果と錠剤着色の高い抑制効果をもつ、エゼチミブを含有する錠剤を製造するための有用な技術的手段を提供すること。【解決手段】エゼチミブ、及び素錠の全重量に対して０．１〜２．８重量％のポビドン等の１−ビニル-２−ピロリドンの重合体、を含む錠剤（好ましくはクロスポビドンを含まない。）を製造する。其の錠剤はエゼチミブを含む造粒物を含有することが望ましく、其の造粒物は攪拌造粒や流動層造粒、噴霧乾燥造粒等の方法によって製造することが可能である。【選択図】なし</description><language>eng ; jpn</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181108&DB=EPODOC&CC=JP&NR=2018172359A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181108&DB=EPODOC&CC=JP&NR=2018172359A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TANAKA YUMA</creatorcontrib><creatorcontrib>UKAI MASARU</creatorcontrib><title>EZETIMIBE-CONTAINING TABLET THAT COMPRISES ADEQUATE AMOUNT OF VINYLPYRROLIDONE POLYMER</title><description>PROBLEM TO BE SOLVED: To provide useful technical means for producing an ezetimibe-containing tablet having chemically stable improving effect of ezetimibe and highly suppressing effect of tablet coloring, when stored under harsh storage conditions.SOLUTION: A tablet (preferably free of crospovidone) that comprises ezetimibe and a polymer of 1-vinyl 2-pyrrolidone, such as 0.1 to 2.8% by weight of povidone with respect to the total amount of an uncoated tablet, is produced. Preferably the tablet contains a granule containing ezetimibe, and the granule is capable of producing by methods, such as stirring granulation, fluid layer granulation, and spray drying granulation.SELECTED DRAWING: None
【課題】本発明は、苛酷な保存条件下で保存した場合における、エゼチミブの化学的な安定性の高い改善効果と錠剤着色の高い抑制効果をもつ、エゼチミブを含有する錠剤を製造するための有用な技術的手段を提供すること。【解決手段】エゼチミブ、及び素錠の全重量に対して０．１〜２．８重量％のポビドン等の１−ビニル-２−ピロリドンの重合体、を含む錠剤（好ましくはクロスポビドンを含まない。）を製造する。其の錠剤はエゼチミブを含む造粒物を含有することが望ましく、其の造粒物は攪拌造粒や流動層造粒、噴霧乾燥造粒等の方法によって製造することが可能である。【選択図】なし</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEOgjAQAFAWB6P-w8WdRCBGHQ84pKbt1XKQ4EKIqZNREvz_uPgBTm95y6ijG4kyKqe4YCuorLJnEMw1CUiNAgUb51VDDWBJ1xaFAA23VoAr6JTtteu9Z61KtgSOdW_Ir6PFY3zOYfNzFW0rkqKOw_QewjyN9_AKn-Hi0l1yTA5ptj9h9lf6AkBPMdg</recordid><startdate>20181108</startdate><enddate>20181108</enddate><creator>TANAKA YUMA</creator><creator>UKAI MASARU</creator><scope>EVB</scope></search><sort><creationdate>20181108</creationdate><title>EZETIMIBE-CONTAINING TABLET THAT COMPRISES ADEQUATE AMOUNT OF VINYLPYRROLIDONE POLYMER</title><author>TANAKA YUMA ; UKAI MASARU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2018172359A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TANAKA YUMA</creatorcontrib><creatorcontrib>UKAI MASARU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TANAKA YUMA</au><au>UKAI MASARU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>EZETIMIBE-CONTAINING TABLET THAT COMPRISES ADEQUATE AMOUNT OF VINYLPYRROLIDONE POLYMER</title><date>2018-11-08</date><risdate>2018</risdate><abstract>PROBLEM TO BE SOLVED: To provide useful technical means for producing an ezetimibe-containing tablet having chemically stable improving effect of ezetimibe and highly suppressing effect of tablet coloring, when stored under harsh storage conditions.SOLUTION: A tablet (preferably free of crospovidone) that comprises ezetimibe and a polymer of 1-vinyl 2-pyrrolidone, such as 0.1 to 2.8% by weight of povidone with respect to the total amount of an uncoated tablet, is produced. Preferably the tablet contains a granule containing ezetimibe, and the granule is capable of producing by methods, such as stirring granulation, fluid layer granulation, and spray drying granulation.SELECTED DRAWING: None
【課題】本発明は、苛酷な保存条件下で保存した場合における、エゼチミブの化学的な安定性の高い改善効果と錠剤着色の高い抑制効果をもつ、エゼチミブを含有する錠剤を製造するための有用な技術的手段を提供すること。【解決手段】エゼチミブ、及び素錠の全重量に対して０．１〜２．８重量％のポビドン等の１−ビニル-２−ピロリドンの重合体、を含む錠剤（好ましくはクロスポビドンを含まない。）を製造する。其の錠剤はエゼチミブを含む造粒物を含有することが望ましく、其の造粒物は攪拌造粒や流動層造粒、噴霧乾燥造粒等の方法によって製造することが可能である。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | EZETIMIBE-CONTAINING TABLET THAT COMPRISES ADEQUATE AMOUNT OF VINYLPYRROLIDONE POLYMER |
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