NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY
PROBLEM TO BE SOLVED: To provide a stable liquid composition with good texture, which is prevented from causing precipitation of a pharmaceutical agent such as guaifenesin, the composition comprising a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol, alone or in combinatio...
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| creator | VANESSA ROSE SHEPPERSON CESAR IVAN SERTZEN SHIVANGI VIJAYKUMAR PATEL ROBERT ALAN FRIEDLINE GARY ROBERT AGISIM |
| description | PROBLEM TO BE SOLVED: To provide a stable liquid composition with good texture, which is prevented from causing precipitation of a pharmaceutical agent such as guaifenesin, the composition comprising a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol, alone or in combination with an additional pharmaceutical agent, such as phenylephrine.SOLUTION: The present invention provides a liquid oral pharmaceutical composition comprising: 0.1 w/v% to 20 w/v% of polyvinyl pyrrolidone; 5 w/v% to 70 w/v% of polyethylene glycol; 1 w/v% to 30 w/v% propylene glycol; 1 w/v% to 10 w/v% guaifenesin; and 0.01 w/v% to 1.0 w/v% of phenylephrine. The composition further comprises one or more pharmaceutical agents selected from analgesics, decongestants, expectorants, antitussives, antipyretics, anti-inflammatory agents, cough suppressants, and antihistamines. The composition causes no visible precipitation of guaifenesin at least 62 days at 4°C.SELECTED DRAWING: None
【課題】ポリエチレングリコール、ポリビニルピロリドン、およびプロピレングリコールの混合物において、単独での、またはフェニレフリンなどの追加の医薬剤と組み合わせた、グアイフェネシンなどの医薬剤の沈澱が阻止され口あたりの良い安定な液体組成物の提供。【解決手段】０．１ｗ／ｖ％〜２０ｗ／ｖ％のポリビニルピロリドン；５ｗ／ｖ％〜７０ｗ／ｖ％のポリエチレングリコール；１ｗ／ｖ％〜３０ｗ／ｖ％のプロピレングリコール；１ｗ／ｖ％〜１０ｗ／ｖ％のグアイフェネシン；および０．０１ｗ／ｖ％〜１．０ｗ／ｖ％のフェニレフリンを含む液体経口医薬組成物であって、さらに、鎮痛薬、うっ血除去薬、去痰薬、鎮咳薬、解熱薬、抗炎症剤、咳止め、および抗ヒスタミン剤から選択される１種または複数の医薬剤を含み、ここで、４℃で少なくとも６２日間グアイフェネシンの沈澱が目視されない組成物。【選択図】なし |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2017078084A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2017078084A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2017078084A3</originalsourceid><addsrcrecordid>eNrjZDDw8w9z9VHw8QwM9XRRcPb3DfAP9gzx9PdTCPcM8VBw9fNw9HN2dVEIDnF08vTxDInkYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBobmBuYWBhYmjsZEKQIAk6Qm_A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY</title><source>esp@cenet</source><creator>VANESSA ROSE SHEPPERSON ; CESAR IVAN SERTZEN ; SHIVANGI VIJAYKUMAR PATEL ; ROBERT ALAN FRIEDLINE ; GARY ROBERT AGISIM</creator><creatorcontrib>VANESSA ROSE SHEPPERSON ; CESAR IVAN SERTZEN ; SHIVANGI VIJAYKUMAR PATEL ; ROBERT ALAN FRIEDLINE ; GARY ROBERT AGISIM</creatorcontrib><description>PROBLEM TO BE SOLVED: To provide a stable liquid composition with good texture, which is prevented from causing precipitation of a pharmaceutical agent such as guaifenesin, the composition comprising a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol, alone or in combination with an additional pharmaceutical agent, such as phenylephrine.SOLUTION: The present invention provides a liquid oral pharmaceutical composition comprising: 0.1 w/v% to 20 w/v% of polyvinyl pyrrolidone; 5 w/v% to 70 w/v% of polyethylene glycol; 1 w/v% to 30 w/v% propylene glycol; 1 w/v% to 10 w/v% guaifenesin; and 0.01 w/v% to 1.0 w/v% of phenylephrine. The composition further comprises one or more pharmaceutical agents selected from analgesics, decongestants, expectorants, antitussives, antipyretics, anti-inflammatory agents, cough suppressants, and antihistamines. The composition causes no visible precipitation of guaifenesin at least 62 days at 4°C.SELECTED DRAWING: None
【課題】ポリエチレングリコール、ポリビニルピロリドン、およびプロピレングリコールの混合物において、単独での、またはフェニレフリンなどの追加の医薬剤と組み合わせた、グアイフェネシンなどの医薬剤の沈澱が阻止され口あたりの良い安定な液体組成物の提供。【解決手段】０．１ｗ／ｖ％〜２０ｗ／ｖ％のポリビニルピロリドン；５ｗ／ｖ％〜７０ｗ／ｖ％のポリエチレングリコール；１ｗ／ｖ％〜３０ｗ／ｖ％のプロピレングリコール；１ｗ／ｖ％〜１０ｗ／ｖ％のグアイフェネシン；および０．０１ｗ／ｖ％〜１．０ｗ／ｖ％のフェニレフリンを含む液体経口医薬組成物であって、さらに、鎮痛薬、うっ血除去薬、去痰薬、鎮咳薬、解熱薬、抗炎症剤、咳止め、および抗ヒスタミン剤から選択される１種または複数の医薬剤を含み、ここで、４℃で少なくとも６２日間グアイフェネシンの沈澱が目視されない組成物。【選択図】なし</description><language>eng ; jpn</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170427&DB=EPODOC&CC=JP&NR=2017078084A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170427&DB=EPODOC&CC=JP&NR=2017078084A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VANESSA ROSE SHEPPERSON</creatorcontrib><creatorcontrib>CESAR IVAN SERTZEN</creatorcontrib><creatorcontrib>SHIVANGI VIJAYKUMAR PATEL</creatorcontrib><creatorcontrib>ROBERT ALAN FRIEDLINE</creatorcontrib><creatorcontrib>GARY ROBERT AGISIM</creatorcontrib><title>NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY</title><description>PROBLEM TO BE SOLVED: To provide a stable liquid composition with good texture, which is prevented from causing precipitation of a pharmaceutical agent such as guaifenesin, the composition comprising a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol, alone or in combination with an additional pharmaceutical agent, such as phenylephrine.SOLUTION: The present invention provides a liquid oral pharmaceutical composition comprising: 0.1 w/v% to 20 w/v% of polyvinyl pyrrolidone; 5 w/v% to 70 w/v% of polyethylene glycol; 1 w/v% to 30 w/v% propylene glycol; 1 w/v% to 10 w/v% guaifenesin; and 0.01 w/v% to 1.0 w/v% of phenylephrine. The composition further comprises one or more pharmaceutical agents selected from analgesics, decongestants, expectorants, antitussives, antipyretics, anti-inflammatory agents, cough suppressants, and antihistamines. The composition causes no visible precipitation of guaifenesin at least 62 days at 4°C.SELECTED DRAWING: None
【課題】ポリエチレングリコール、ポリビニルピロリドン、およびプロピレングリコールの混合物において、単独での、またはフェニレフリンなどの追加の医薬剤と組み合わせた、グアイフェネシンなどの医薬剤の沈澱が阻止され口あたりの良い安定な液体組成物の提供。【解決手段】０．１ｗ／ｖ％〜２０ｗ／ｖ％のポリビニルピロリドン；５ｗ／ｖ％〜７０ｗ／ｖ％のポリエチレングリコール；１ｗ／ｖ％〜３０ｗ／ｖ％のプロピレングリコール；１ｗ／ｖ％〜１０ｗ／ｖ％のグアイフェネシン；および０．０１ｗ／ｖ％〜１．０ｗ／ｖ％のフェニレフリンを含む液体経口医薬組成物であって、さらに、鎮痛薬、うっ血除去薬、去痰薬、鎮咳薬、解熱薬、抗炎症剤、咳止め、および抗ヒスタミン剤から選択される１種または複数の医薬剤を含み、ここで、４℃で少なくとも６２日間グアイフェネシンの沈澱が目視されない組成物。【選択図】なし</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDw8w9z9VHw8QwM9XRRcPb3DfAP9gzx9PdTCPcM8VBw9fNw9HN2dVEIDnF08vTxDInkYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBobmBuYWBhYmjsZEKQIAk6Qm_A</recordid><startdate>20170427</startdate><enddate>20170427</enddate><creator>VANESSA ROSE SHEPPERSON</creator><creator>CESAR IVAN SERTZEN</creator><creator>SHIVANGI VIJAYKUMAR PATEL</creator><creator>ROBERT ALAN FRIEDLINE</creator><creator>GARY ROBERT AGISIM</creator><scope>EVB</scope></search><sort><creationdate>20170427</creationdate><title>NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY</title><author>VANESSA ROSE SHEPPERSON ; CESAR IVAN SERTZEN ; SHIVANGI VIJAYKUMAR PATEL ; ROBERT ALAN FRIEDLINE ; GARY ROBERT AGISIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2017078084A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2017</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VANESSA ROSE SHEPPERSON</creatorcontrib><creatorcontrib>CESAR IVAN SERTZEN</creatorcontrib><creatorcontrib>SHIVANGI VIJAYKUMAR PATEL</creatorcontrib><creatorcontrib>ROBERT ALAN FRIEDLINE</creatorcontrib><creatorcontrib>GARY ROBERT AGISIM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VANESSA ROSE SHEPPERSON</au><au>CESAR IVAN SERTZEN</au><au>SHIVANGI VIJAYKUMAR PATEL</au><au>ROBERT ALAN FRIEDLINE</au><au>GARY ROBERT AGISIM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY</title><date>2017-04-27</date><risdate>2017</risdate><abstract>PROBLEM TO BE SOLVED: To provide a stable liquid composition with good texture, which is prevented from causing precipitation of a pharmaceutical agent such as guaifenesin, the composition comprising a mixture of polyethylene glycol, polyvinylpyrrolidone, and propylene glycol, alone or in combination with an additional pharmaceutical agent, such as phenylephrine.SOLUTION: The present invention provides a liquid oral pharmaceutical composition comprising: 0.1 w/v% to 20 w/v% of polyvinyl pyrrolidone; 5 w/v% to 70 w/v% of polyethylene glycol; 1 w/v% to 30 w/v% propylene glycol; 1 w/v% to 10 w/v% guaifenesin; and 0.01 w/v% to 1.0 w/v% of phenylephrine. The composition further comprises one or more pharmaceutical agents selected from analgesics, decongestants, expectorants, antitussives, antipyretics, anti-inflammatory agents, cough suppressants, and antihistamines. The composition causes no visible precipitation of guaifenesin at least 62 days at 4°C.SELECTED DRAWING: None
【課題】ポリエチレングリコール、ポリビニルピロリドン、およびプロピレングリコールの混合物において、単独での、またはフェニレフリンなどの追加の医薬剤と組み合わせた、グアイフェネシンなどの医薬剤の沈澱が阻止され口あたりの良い安定な液体組成物の提供。【解決手段】０．１ｗ／ｖ％〜２０ｗ／ｖ％のポリビニルピロリドン；５ｗ／ｖ％〜７０ｗ／ｖ％のポリエチレングリコール；１ｗ／ｖ％〜３０ｗ／ｖ％のプロピレングリコール；１ｗ／ｖ％〜１０ｗ／ｖ％のグアイフェネシン；および０．０１ｗ／ｖ％〜１．０ｗ／ｖ％のフェニレフリンを含む液体経口医薬組成物であって、さらに、鎮痛薬、うっ血除去薬、去痰薬、鎮咳薬、解熱薬、抗炎症剤、咳止め、および抗ヒスタミン剤から選択される１種または複数の医薬剤を含み、ここで、４℃で少なくとも６２日間グアイフェネシンの沈澱が目視されない組成物。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| title | NOVEL LIQUID COMPOSITION WITH ENHANCED STABILITY |
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