METHOD OF PACKING CHROMATOGRAPHIC COLUMNS, PACKED CHROMATOGRAPHIC COLUMNS FOR USE UNDER HIGH PRESSURE, AND USES THEREOF
PROBLEM TO BE SOLVED: To provide methods of packing chromatographic columns and the like that can withstand high operating pressures, especially above 1000 bar.SOLUTION: A method of packing a chromatography column includes; dispersing chromatographic media particles in a slurry solution to form a sl...
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| creator | LIU XIAODONG MARK L TRACY RONALD A SHERANT JENNIFER M NGUYEN |
| description | PROBLEM TO BE SOLVED: To provide methods of packing chromatographic columns and the like that can withstand high operating pressures, especially above 1000 bar.SOLUTION: A method of packing a chromatography column includes; dispersing chromatographic media particles in a slurry solution to form a slurry; filling a chromatography column with the chromatographic media particles by introducing the slurry to the column; and applying a pressure to pack the chromatographic media particles in the chromatography column. The slurry solution is preferably an aqueous slurry solution. As for the application of the pressure, a preferable method is applying a first pressure for a first period while maintaining the pressure substantially constant, and then applying a second pressure higher than the first pressure for a second period while maintaining the pressure substantially constant.SELECTED DRAWING: Figure 1
【課題】高い操作圧、特に１０００バール超に耐え得る、かかるカラムの充填方法等を提供すること。【解決手段】クロマトグラフィーカラムを充填する方法であって、クロマトグラフィー媒体粒子をスラリー溶液中に分散させてスラリーを形成することと、スラリーをカラムに導入することによってクロマトグラフィーカラムをクロマトグラフィー媒体粒子で満たすことと、圧力を加えてクロマトグラフィー媒体粒子をクロマトグラフィーカラム内に充填することと、を含む、方法を提供する。このスラリー溶液は、好ましくは水系スラリー溶液である。この圧力は、好ましくは、第１の期間にわたって第１の圧力で加えられ、かつ実質的に一定に保たれ、また、第１の期間の後、第２の期間にわたって第１の圧力よりも高い第２の圧力で加えられ、かつ実質的に一定に保たれる。【選択図】図１ |
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【課題】高い操作圧、特に１０００バール超に耐え得る、かかるカラムの充填方法等を提供すること。【解決手段】クロマトグラフィーカラムを充填する方法であって、クロマトグラフィー媒体粒子をスラリー溶液中に分散させてスラリーを形成することと、スラリーをカラムに導入することによってクロマトグラフィーカラムをクロマトグラフィー媒体粒子で満たすことと、圧力を加えてクロマトグラフィー媒体粒子をクロマトグラフィーカラム内に充填することと、を含む、方法を提供する。このスラリー溶液は、好ましくは水系スラリー溶液である。この圧力は、好ましくは、第１の期間にわたって第１の圧力で加えられ、かつ実質的に一定に保たれ、また、第１の期間の後、第２の期間にわたって第１の圧力よりも高い第２の圧力で加えられ、かつ実質的に一定に保たれる。【選択図】図１</description><language>eng ; jpn</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170406&DB=EPODOC&CC=JP&NR=2017067780A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170406&DB=EPODOC&CC=JP&NR=2017067780A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU XIAODONG</creatorcontrib><creatorcontrib>MARK L TRACY</creatorcontrib><creatorcontrib>RONALD A SHERANT</creatorcontrib><creatorcontrib>JENNIFER M NGUYEN</creatorcontrib><title>METHOD OF PACKING CHROMATOGRAPHIC COLUMNS, PACKED CHROMATOGRAPHIC COLUMNS FOR USE UNDER HIGH PRESSURE, AND USES THEREOF</title><description>PROBLEM TO BE SOLVED: To provide methods of packing chromatographic columns and the like that can withstand high operating pressures, especially above 1000 bar.SOLUTION: A method of packing a chromatography column includes; dispersing chromatographic media particles in a slurry solution to form a slurry; filling a chromatography column with the chromatographic media particles by introducing the slurry to the column; and applying a pressure to pack the chromatographic media particles in the chromatography column. The slurry solution is preferably an aqueous slurry solution. As for the application of the pressure, a preferable method is applying a first pressure for a first period while maintaining the pressure substantially constant, and then applying a second pressure higher than the first pressure for a second period while maintaining the pressure substantially constant.SELECTED DRAWING: Figure 1
【課題】高い操作圧、特に１０００バール超に耐え得る、かかるカラムの充填方法等を提供すること。【解決手段】クロマトグラフィーカラムを充填する方法であって、クロマトグラフィー媒体粒子をスラリー溶液中に分散させてスラリーを形成することと、スラリーをカラムに導入することによってクロマトグラフィーカラムをクロマトグラフィー媒体粒子で満たすことと、圧力を加えてクロマトグラフィー媒体粒子をクロマトグラフィーカラム内に充填することと、を含む、方法を提供する。このスラリー溶液は、好ましくは水系スラリー溶液である。この圧力は、好ましくは、第１の期間にわたって第１の圧力で加えられ、かつ実質的に一定に保たれ、また、第１の期間の後、第２の期間にわたって第１の圧力よりも高い第２の圧力で加えられ、かつ実質的に一定に保たれる。【選択図】図１</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w-FcoSoY15BcelWbhEsylyJxEi1U8PVFcRWc_uH7p8WzxUhOgzPgpTo2tgZF7FoZXc3SU6NAuVNqbSg_A-pfDsYxpICQrEYGamoCzxhCYixBWv3GAJGQ0Zl5Mbn01zEvvp0VS4NR0SoP9y6PQ3_Ot_zoDn5TrUW1E2Jfye1f0wvCPzoU</recordid><startdate>20170406</startdate><enddate>20170406</enddate><creator>LIU XIAODONG</creator><creator>MARK L TRACY</creator><creator>RONALD A SHERANT</creator><creator>JENNIFER M NGUYEN</creator><scope>EVB</scope></search><sort><creationdate>20170406</creationdate><title>METHOD OF PACKING CHROMATOGRAPHIC COLUMNS, PACKED CHROMATOGRAPHIC COLUMNS FOR USE UNDER HIGH PRESSURE, AND USES THEREOF</title><author>LIU XIAODONG ; MARK L TRACY ; RONALD A SHERANT ; JENNIFER M NGUYEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2017067780A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2017</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU XIAODONG</creatorcontrib><creatorcontrib>MARK L TRACY</creatorcontrib><creatorcontrib>RONALD A SHERANT</creatorcontrib><creatorcontrib>JENNIFER M NGUYEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU XIAODONG</au><au>MARK L TRACY</au><au>RONALD A SHERANT</au><au>JENNIFER M NGUYEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF PACKING CHROMATOGRAPHIC COLUMNS, PACKED CHROMATOGRAPHIC COLUMNS FOR USE UNDER HIGH PRESSURE, AND USES THEREOF</title><date>2017-04-06</date><risdate>2017</risdate><abstract>PROBLEM TO BE SOLVED: To provide methods of packing chromatographic columns and the like that can withstand high operating pressures, especially above 1000 bar.SOLUTION: A method of packing a chromatography column includes; dispersing chromatographic media particles in a slurry solution to form a slurry; filling a chromatography column with the chromatographic media particles by introducing the slurry to the column; and applying a pressure to pack the chromatographic media particles in the chromatography column. The slurry solution is preferably an aqueous slurry solution. As for the application of the pressure, a preferable method is applying a first pressure for a first period while maintaining the pressure substantially constant, and then applying a second pressure higher than the first pressure for a second period while maintaining the pressure substantially constant.SELECTED DRAWING: Figure 1
【課題】高い操作圧、特に１０００バール超に耐え得る、かかるカラムの充填方法等を提供すること。【解決手段】クロマトグラフィーカラムを充填する方法であって、クロマトグラフィー媒体粒子をスラリー溶液中に分散させてスラリーを形成することと、スラリーをカラムに導入することによってクロマトグラフィーカラムをクロマトグラフィー媒体粒子で満たすことと、圧力を加えてクロマトグラフィー媒体粒子をクロマトグラフィーカラム内に充填することと、を含む、方法を提供する。このスラリー溶液は、好ましくは水系スラリー溶液である。この圧力は、好ましくは、第１の期間にわたって第１の圧力で加えられ、かつ実質的に一定に保たれ、また、第１の期間の後、第２の期間にわたって第１の圧力よりも高い第２の圧力で加えられ、かつ実質的に一定に保たれる。【選択図】図１</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | METHOD OF PACKING CHROMATOGRAPHIC COLUMNS, PACKED CHROMATOGRAPHIC COLUMNS FOR USE UNDER HIGH PRESSURE, AND USES THEREOF |
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