NOVEL CRYSTALLINE FORMS OF DIPEPTIDYL PEPTIDASE-IV INHIBITOR

PROBLEM TO BE SOLVED: To provide novel crystalline forms of a dipeptidyl peptidase-IV inhibitor.SOLUTION: The present invention provides crystalline (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine, represented by compound (I), which has following four peaks in a powder X-ray diffraction pattern: 17.8±0.1 2θ, 19.2±0.1 2θ, 22.2±0.1 2θ and 24.1±0.1 2θ.SELECTED DRAWING: Figure 16 【課題】ジペプチジルペプチダーゼ−ＩＶ阻害剤の新規結晶形の提供。【解決手段】化合物（Ｉ）で表される結晶質（２Ｒ，３Ｓ，５Ｒ）−２−（２，５−ジフルオロフェニル）−５−［２−（メチルスルホニル）−２，６−ジヒドロピロロ［３，４−ｃ］ピラゾール−５（４Ｈ）−イル］テトラヒドロ−２Ｈ−ピラン−３−アミン。粉末Ｘ線回折パターンにおける次の４ピーク：１７．８±０．１ ２θ、１９．２±０．１ ２θ、２２．２±０．１ ２θ及び２４．１±０．１ ２θを有する。【選択図】図１６