TABLETS FOR ORAL ADMINISTRATION
PROBLEM TO BE SOLVED: To provide tablets that have high in vivo drug dispersibility and hardly cause swelling of a drug housing part in a packaging body by suppressing the generation of carbonic acid gas associated with times.SOLUTION: A tablet contains (A) a particle group containing a poorly water...
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| Zusammenfassung: | PROBLEM TO BE SOLVED: To provide tablets that have high in vivo drug dispersibility and hardly cause swelling of a drug housing part in a packaging body by suppressing the generation of carbonic acid gas associated with times.SOLUTION: A tablet contains (A) a particle group containing a poorly water-soluble drug (a1) particle group with a solubility to water at 20°C of 13 mg/mL or less, a particle group of hydrogen carbonate (b1), and a particle group of at least one kind of carbonate (b2) selected from sodium carbonate and calcium carbonate, wherein the mass ratio represented by component (b1)/component (b2) is two or less.SELECTED DRAWING: None
【課題】体内での薬物の分散性が高く、かつ、経時に伴う炭酸ガスの発生が抑えられて包装体における薬物収容部の膨張を生じにくい錠剤を提供する。【解決手段】２０℃の水に対する溶解度が１３ｍｇ／ｍＬ以下の水難溶性薬物（ａ１）の粒子群を含有する粒子群（Ａ）と、炭酸水素塩（ｂ１）の粒子群と、炭酸ナトリウム及び炭酸カルシウムから選択される少なくとも１種の炭酸塩（ｂ２）の粒子群と、を含有し、（ｂ１）成分／（ｂ２）成分で表される質量比が２以下である、錠剤。【選択図】なし |
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