METHOD AND MEANS FOR TREATMENT OF OSTEOARTHRITIS

PROBLEM TO BE SOLVED: To provide methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM (ExtraCellular Matrix).SOLUTION: A method for identifying a compound includes: contacting a compound that inhibits a...

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Hauptverfasser:	BLANDINE MILLE-BAKER, REGINALD CHRISTOPHE XAVIER BRYS, MICHELA ANGELA TESSARI, LUC NELLES, NICK ERNEST RENE VANDEGHINSTE
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM (ExtraCellular Matrix).SOLUTION: A method for identifying a compound includes: contacting a compound that inhibits an extracellular matrix (ECM) and/or cartilage degradation with a polypeptide or a functional fragment thereof, under conditions that allow the polypeptide to bind to the compound, and measuring a compound-polypeptide property related to the inhibition of ECM and/or cartilage degradation.SELECTED DRAWING: Figure 1 【課題】軟骨細胞における異化過程を阻害し、かつ軟骨及び／又はECMの変性を低下させる化合物を同定する方法及び手段を提供する。【解決手段】細胞外マトリックス（ECM）及び／又は軟骨変性過程を低下させる化合物を、ポリペプチド又はその機能的断片と、ポリペプチドが化合物に結合できる条件下で接触させることと、ECM及び／又は軟骨の変性の阻害と関連した化合物-ポリペプチド特性を測定することとを含む、化合物を同定する方法。【選択図】図１