ORAL SOLID TABLET
PROBLEM TO BE SOLVED: To provide an oral solid tablet which has high dispersibility in a body, and reduction of tablet hardness with time is suppressed.SOLUTION: An oral solid tablet of the present invention contains: granulation particles (A) containing a poorly water-soluble drug (a1) with 5 mg/mL...
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| creator | OTANI AKI TACHIBANA MASAAKI |
| description | PROBLEM TO BE SOLVED: To provide an oral solid tablet which has high dispersibility in a body, and reduction of tablet hardness with time is suppressed.SOLUTION: An oral solid tablet of the present invention contains: granulation particles (A) containing a poorly water-soluble drug (a1) with 5 mg/mL or less of solubility to water at 20°C, one kind or more of a polymeric compound (a2) selected from the group consisting of a water-swellable polymeric compound with 1000 or more of molecular weight and a water-soluble polymeric compound with 1 mg/mL or more of solubility to water at 20°C and molecular weight of 1000 or more, and water-soluble powder (a3) (excluding particles (B) below) with higher than 5 mg/mL of solubility to water at 20°C and molecular weight of less than 1000; and particles (B) made of one kind or more of a compound selected from the group consisting of hydrogen carbonate and carbonate.
【課題】体内での薬物の分散性が高く、かつ、経時に伴う錠剤硬度の低下が抑制された内服固形錠剤を提供すること。【解決手段】本発明の内服固形錠剤は、２０℃の水に対する溶解度が５ｍｇ／ｍＬ以下の水難溶性薬物（ａ１）、分子量が１０００以上の水膨潤性高分子化合物、及び２０℃の水に対する溶解度が１ｍｇ／ｍＬ以上であり、分子量が１０００以上の水溶性高分子化合物からなる群より選ばれる１種以上の高分子化合物（ａ２）、並びに、２０℃の水に対する溶解度が５ｍｇ／ｍＬ超であり、分子量が１０００未満の水溶性粉体（ａ３）（但し、下記粒子（Ｂ）を除く）を含む造粒粒子（Ａ）と、炭酸水素塩及び炭酸塩からなる群より選ばれる１種以上の化合物からなる粒子（Ｂ）と、を含有する。【選択図】なし |
| format | Patent |
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【課題】体内での薬物の分散性が高く、かつ、経時に伴う錠剤硬度の低下が抑制された内服固形錠剤を提供すること。【解決手段】本発明の内服固形錠剤は、２０℃の水に対する溶解度が５ｍｇ／ｍＬ以下の水難溶性薬物（ａ１）、分子量が１０００以上の水膨潤性高分子化合物、及び２０℃の水に対する溶解度が１ｍｇ／ｍＬ以上であり、分子量が１０００以上の水溶性高分子化合物からなる群より選ばれる１種以上の高分子化合物（ａ２）、並びに、２０℃の水に対する溶解度が５ｍｇ／ｍＬ超であり、分子量が１０００未満の水溶性粉体（ａ３）（但し、下記粒子（Ｂ）を除く）を含む造粒粒子（Ａ）と、炭酸水素塩及び炭酸塩からなる群より選ばれる１種以上の化合物からなる粒子（Ｂ）と、を含有する。【選択図】なし</description><language>eng ; jpn</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151126&DB=EPODOC&CC=JP&NR=2015212258A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151126&DB=EPODOC&CC=JP&NR=2015212258A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OTANI AKI</creatorcontrib><creatorcontrib>TACHIBANA MASAAKI</creatorcontrib><title>ORAL SOLID TABLET</title><description>PROBLEM TO BE SOLVED: To provide an oral solid tablet which has high dispersibility in a body, and reduction of tablet hardness with time is suppressed.SOLUTION: An oral solid tablet of the present invention contains: granulation particles (A) containing a poorly water-soluble drug (a1) with 5 mg/mL or less of solubility to water at 20°C, one kind or more of a polymeric compound (a2) selected from the group consisting of a water-swellable polymeric compound with 1000 or more of molecular weight and a water-soluble polymeric compound with 1 mg/mL or more of solubility to water at 20°C and molecular weight of 1000 or more, and water-soluble powder (a3) (excluding particles (B) below) with higher than 5 mg/mL of solubility to water at 20°C and molecular weight of less than 1000; and particles (B) made of one kind or more of a compound selected from the group consisting of hydrogen carbonate and carbonate.
【課題】体内での薬物の分散性が高く、かつ、経時に伴う錠剤硬度の低下が抑制された内服固形錠剤を提供すること。【解決手段】本発明の内服固形錠剤は、２０℃の水に対する溶解度が５ｍｇ／ｍＬ以下の水難溶性薬物（ａ１）、分子量が１０００以上の水膨潤性高分子化合物、及び２０℃の水に対する溶解度が１ｍｇ／ｍＬ以上であり、分子量が１０００以上の水溶性高分子化合物からなる群より選ばれる１種以上の高分子化合物（ａ２）、並びに、２０℃の水に対する溶解度が５ｍｇ／ｍＬ超であり、分子量が１０００未満の水溶性粉体（ａ３）（但し、下記粒子（Ｂ）を除く）を含む造粒粒子（Ａ）と、炭酸水素塩及び炭酸塩からなる群より選ばれる１種以上の化合物からなる粒子（Ｂ）と、を含有する。【選択図】なし</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD0D3L0UQj29_F0UQhxdPJxDeFhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfFeAUYGhqZGhkZGphaOxkQpAgBKlR4J</recordid><startdate>20151126</startdate><enddate>20151126</enddate><creator>OTANI AKI</creator><creator>TACHIBANA MASAAKI</creator><scope>EVB</scope></search><sort><creationdate>20151126</creationdate><title>ORAL SOLID TABLET</title><author>OTANI AKI ; TACHIBANA MASAAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2015212258A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2015</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>OTANI AKI</creatorcontrib><creatorcontrib>TACHIBANA MASAAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OTANI AKI</au><au>TACHIBANA MASAAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ORAL SOLID TABLET</title><date>2015-11-26</date><risdate>2015</risdate><abstract>PROBLEM TO BE SOLVED: To provide an oral solid tablet which has high dispersibility in a body, and reduction of tablet hardness with time is suppressed.SOLUTION: An oral solid tablet of the present invention contains: granulation particles (A) containing a poorly water-soluble drug (a1) with 5 mg/mL or less of solubility to water at 20°C, one kind or more of a polymeric compound (a2) selected from the group consisting of a water-swellable polymeric compound with 1000 or more of molecular weight and a water-soluble polymeric compound with 1 mg/mL or more of solubility to water at 20°C and molecular weight of 1000 or more, and water-soluble powder (a3) (excluding particles (B) below) with higher than 5 mg/mL of solubility to water at 20°C and molecular weight of less than 1000; and particles (B) made of one kind or more of a compound selected from the group consisting of hydrogen carbonate and carbonate.
【課題】体内での薬物の分散性が高く、かつ、経時に伴う錠剤硬度の低下が抑制された内服固形錠剤を提供すること。【解決手段】本発明の内服固形錠剤は、２０℃の水に対する溶解度が５ｍｇ／ｍＬ以下の水難溶性薬物（ａ１）、分子量が１０００以上の水膨潤性高分子化合物、及び２０℃の水に対する溶解度が１ｍｇ／ｍＬ以上であり、分子量が１０００以上の水溶性高分子化合物からなる群より選ばれる１種以上の高分子化合物（ａ２）、並びに、２０℃の水に対する溶解度が５ｍｇ／ｍＬ超であり、分子量が１０００未満の水溶性粉体（ａ３）（但し、下記粒子（Ｂ）を除く）を含む造粒粒子（Ａ）と、炭酸水素塩及び炭酸塩からなる群より選ばれる１種以上の化合物からなる粒子（Ｂ）と、を含有する。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| title | ORAL SOLID TABLET |
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