COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG
PROBLEM TO BE SOLVED: To provide a composition of a complex containing a biologically active peptide and a formulation and the use of the same.SOLUTION: The present invention relates to a treatment method for increasing a blood flow to various organs under reduced blood volume and reduced blood pres...
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| creator | GERARDO M CASTILLO ELIJAH M BOLOTIN CHAN ELAINE K |
| description | PROBLEM TO BE SOLVED: To provide a composition of a complex containing a biologically active peptide and a formulation and the use of the same.SOLUTION: The present invention relates to a treatment method for increasing a blood flow to various organs under reduced blood volume and reduced blood pressure and increasing a level of a factor VIII and a plasminogen activator in blood, using a group of novel long-acting vasopressin analogs and formulations and compounds of the same. More specifically, the present invention relates to vasopressin and a biologically active polypeptide derivative of the vasopressin, obtained by modification of forming a covalent bond at a binding site so as to generate a long-acting analog of the polypeptide, considered to act by a controlled release of active vasopressin or a vasopressin derivative.
【課題】生物学的に活性なペプチドを含有する錯体の組成物、このような組成物の調合物及び使用法を提供する。【解決手段】本発明は、一群の新規な長期作用性バソプレッシン類似体、それらの調合物や、これらの化合物を用いて、血液量減少及び血圧低下状況における多様な臓器への血流を増加させたり、血液中の第ＶＩＩＩ因子及びプラスミノーゲン活性化因子のレベルを増加させたりするための処置法に関する。より具体的には、本発明は、バソプレッシンと、活性バソプレッシン又はバソプレッシン誘導体の徐放により働くと考えられる当該ポリペプチドの長期作用性類似体を生じるように結合性部分を共有結合させる修飾を施してある、バソプレッシンの生物学的に活性なポリペプチド誘導体とに関する。【選択図】なし |
| format | Patent |
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【課題】生物学的に活性なペプチドを含有する錯体の組成物、このような組成物の調合物及び使用法を提供する。【解決手段】本発明は、一群の新規な長期作用性バソプレッシン類似体、それらの調合物や、これらの化合物を用いて、血液量減少及び血圧低下状況における多様な臓器への血流を増加させたり、血液中の第ＶＩＩＩ因子及びプラスミノーゲン活性化因子のレベルを増加させたりするための処置法に関する。より具体的には、本発明は、バソプレッシンと、活性バソプレッシン又はバソプレッシン誘導体の徐放により働くと考えられる当該ポリペプチドの長期作用性類似体を生じるように結合性部分を共有結合させる修飾を施してある、バソプレッシンの生物学的に活性なポリペプチド誘導体とに関する。【選択図】なし</description><language>eng ; jpn</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150618&DB=EPODOC&CC=JP&NR=2015110662A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150618&DB=EPODOC&CC=JP&NR=2015110662A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GERARDO M CASTILLO</creatorcontrib><creatorcontrib>ELIJAH M BOLOTIN</creatorcontrib><creatorcontrib>CHAN ELAINE K</creatorcontrib><title>COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG</title><description>PROBLEM TO BE SOLVED: To provide a composition of a complex containing a biologically active peptide and a formulation and the use of the same.SOLUTION: The present invention relates to a treatment method for increasing a blood flow to various organs under reduced blood volume and reduced blood pressure and increasing a level of a factor VIII and a plasminogen activator in blood, using a group of novel long-acting vasopressin analogs and formulations and compounds of the same. More specifically, the present invention relates to vasopressin and a biologically active polypeptide derivative of the vasopressin, obtained by modification of forming a covalent bond at a binding site so as to generate a long-acting analog of the polypeptide, considered to act by a controlled release of active vasopressin or a vasopressin derivative.
【課題】生物学的に活性なペプチドを含有する錯体の組成物、このような組成物の調合物及び使用法を提供する。【解決手段】本発明は、一群の新規な長期作用性バソプレッシン類似体、それらの調合物や、これらの化合物を用いて、血液量減少及び血圧低下状況における多様な臓器への血流を増加させたり、血液中の第ＶＩＩＩ因子及びプラスミノーゲン活性化因子のレベルを増加させたりするための処置法に関する。より具体的には、本発明は、バソプレッシンと、活性バソプレッシン又はバソプレッシン誘導体の徐放により働くと考えられる当該ポリペプチドの長期作用性類似体を生じるように結合性部分を共有結合させる修飾を施してある、バソプレッシンの生物学的に活性なポリペプチド誘導体とに関する。【選択図】なし</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBy9vcN8A_2DPH091Nw8w9S8PH3c9d1dA7x9HNXCHANCPF0cVVw9HP08XfnYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBoamhoYGZmZGjsZEKQIAmNwlAA</recordid><startdate>20150618</startdate><enddate>20150618</enddate><creator>GERARDO M CASTILLO</creator><creator>ELIJAH M BOLOTIN</creator><creator>CHAN ELAINE K</creator><scope>EVB</scope></search><sort><creationdate>20150618</creationdate><title>COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG</title><author>GERARDO M CASTILLO ; ELIJAH M BOLOTIN ; CHAN ELAINE K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2015110662A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2015</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GERARDO M CASTILLO</creatorcontrib><creatorcontrib>ELIJAH M BOLOTIN</creatorcontrib><creatorcontrib>CHAN ELAINE K</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GERARDO M CASTILLO</au><au>ELIJAH M BOLOTIN</au><au>CHAN ELAINE K</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG</title><date>2015-06-18</date><risdate>2015</risdate><abstract>PROBLEM TO BE SOLVED: To provide a composition of a complex containing a biologically active peptide and a formulation and the use of the same.SOLUTION: The present invention relates to a treatment method for increasing a blood flow to various organs under reduced blood volume and reduced blood pressure and increasing a level of a factor VIII and a plasminogen activator in blood, using a group of novel long-acting vasopressin analogs and formulations and compounds of the same. More specifically, the present invention relates to vasopressin and a biologically active polypeptide derivative of the vasopressin, obtained by modification of forming a covalent bond at a binding site so as to generate a long-acting analog of the polypeptide, considered to act by a controlled release of active vasopressin or a vasopressin derivative.
【課題】生物学的に活性なペプチドを含有する錯体の組成物、このような組成物の調合物及び使用法を提供する。【解決手段】本発明は、一群の新規な長期作用性バソプレッシン類似体、それらの調合物や、これらの化合物を用いて、血液量減少及び血圧低下状況における多様な臓器への血流を増加させたり、血液中の第ＶＩＩＩ因子及びプラスミノーゲン活性化因子のレベルを増加させたりするための処置法に関する。より具体的には、本発明は、バソプレッシンと、活性バソプレッシン又はバソプレッシン誘導体の徐放により働くと考えられる当該ポリペプチドの長期作用性類似体を生じるように結合性部分を共有結合させる修飾を施してある、バソプレッシンの生物学的に活性なポリペプチド誘導体とに関する。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOSITION FOR LONG-ACTING PEPTIDE ANALOG |
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