SUBSTANCE-DELIVERING CARRIER FOR PRODUCTIVE CELLS OF FUCOSYLATED SUGAR CHAIN
PROBLEM TO BE SOLVED: To provide a carrier for delivering a substance, for treating tumor diseases, specifically to productive cells of fucosylated sugar chain.SOLUTION: Provided is a carrier for delivering a substance to productive cells of fucosylated sugar chain comprising a fucose. The carrier i...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To provide a carrier for delivering a substance, for treating tumor diseases, specifically to productive cells of fucosylated sugar chain.SOLUTION: Provided is a carrier for delivering a substance to productive cells of fucosylated sugar chain comprising a fucose. The carrier is selected from the group consisting of tumor cells in which a production amount of a fucosylated sugar chain in fucosylated sugar chain-producing cells is two times or more than that in a normal cells, and tumor cells in which the concentration of CA 19-9, Span-1, or Dupan-2 in the supernatant obtained by culturing 5×10cells in a culture medium of 3 ml for 48 hours becomes 150 U/ml or more, 94 U/ml or more, or 80 U/ml or more respectively.
【課題】腫瘍性疾患を処置するための、フコシル化糖鎖産生細胞特異的に物質を送達する担体の提供。【解決手段】フコースを含む、フコシル化糖鎖産生細胞に物質を送達するための担体であって、フコシル化糖鎖産生細胞が、フコシル化糖鎖産生量が正常細胞に比べ2倍以上である腫瘍細胞、及び5?106個の細胞を3mlの培地中で48時間培養した上清中のCA19−9、Span−1またはDupan−2の濃度が、それぞれ、150U/ml以上、94U/ml以上または80U/ml以上となる腫瘍細胞、からなる群から選択される、前記担体。【選択図】なし |
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