FACTOR IXA FOR TREATMENT OF BLEEDING DISORDER

PROBLEM TO BE SOLVED: To provide a method for treatment of blood coagulation pathologies by pharmaceutical preparations containing Factor IXa.SOLUTION: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The method i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BAKER DONALD A, DONOVAN SHANE
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for treatment of blood coagulation pathologies by pharmaceutical preparations containing Factor IXa.SOLUTION: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The method includes a step of administering a pharmaceutical preparation containing at least 10% Factor IXa (mg/mg total protein). The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides a method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity.