IMPROVED METHOD FOR MAKING ANALGESIC
PROBLEM TO BE SOLVED: To provide an improved analgesic oxymorphone hydrochloride.SOLUTION: The invention relates to a pharmaceutical preparation which comprises oxymorphone hydrochloride containing less than 10 ppm of a 14-hydroxymorphinone. This oxymorphone hydrochloride is produced by reducing a s...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | PROBLEM TO BE SOLVED: To provide an improved analgesic oxymorphone hydrochloride.SOLUTION: The invention relates to a pharmaceutical preparation which comprises oxymorphone hydrochloride containing less than 10 ppm of a 14-hydroxymorphinone. This oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration. |
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