CONTROLLED-RELEASE TYPE TAMSULOSIN TABLET

CONTROLLED-RELEASE TYPE TAMSULOSIN TABLET

PROBLEM TO BE SOLVED: To provide a controlled-release type tamsulosin tablet exhibiting substantially no food effect. SOLUTION: The controlled-release type tablet includes: a tablet matrix with tamsulosin or a pharmaceutically acceptable salt thereof dispersed therein; and optionally an enteric coat...

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Hauptverfasser: ORTEGA ARTURO SILES, PLATTEEUW JOHANNES JAN, ESCOI JUAN CUCALA, LEMMENS JACOBUS MARIA, DALEN FRANS VAN
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ORTEGA ARTURO SILES
PLATTEEUW JOHANNES JAN
ESCOI JUAN CUCALA
LEMMENS JACOBUS MARIA
DALEN FRANS VAN
description PROBLEM TO BE SOLVED: To provide a controlled-release type tamsulosin tablet exhibiting substantially no food effect. SOLUTION: The controlled-release type tablet includes: a tablet matrix with tamsulosin or a pharmaceutically acceptable salt thereof dispersed therein; and optionally an enteric coating over the matrix. In the tablet, the matrix component is selected from the group consisting of a water-swelling cellulose derivative, sodium alginate, acrylates, methacrylates, copolymers of them with various comonomers, and polyvinyl pyrrolidones; and the water-swelling cellulose derivative is hydroxypropylmethylcellulose or the like. The tablet exhibits such an elution profile that: in each of the media SIF, FaSSIF, and FeSSIF, the tablet releases not more than 60% of the tamsulosin after the lapse of 2 h in USP 2 apparatus using 500 mL of either one of the media at a paddle speed of 50-100 rpm. COPYRIGHT: (C)2011,JPO&INPIT
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CONTROLLED-RELEASE TYPE TAMSULOSIN TABLET
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