PROCESS FOR PREPARATION OF (1S, 4R)-OR (1R, 4S)-4-(2-AMINO-6-CHLORO-9H-PURINE-9-YL)-2-CYCLOPENTENE-1-METHANOL

PROBLEM TO BE SOLVED: To provide a process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative useful for a medicinal intermediate. SOLUTION: The process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative (XIII) represented by formula XIII includes the first stage wherein...

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Hauptverfasser:	BURGDORF KURT, O'MURCHU COLM DR, ETTER KAY-SARA, DUC LAURENT DR, BRIEDEN WALTER DR, BERNEGGER CHRISTINE DR, BOSSARD PIERRE DR, BIRCH OLWEN MARY DR, BRUX FRANK, GUGGISBERG YVES DR, GORDON JOHN, URBAN EVA-MARIA
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative useful for a medicinal intermediate. SOLUTION: The process for preparation of a 4-(hydroxymethyl)-2-cyclopentene derivative (XIII) represented by formula XIII includes the first stage wherein one of a racemic substance or an optically active isomer of 4-amino-2-cyclopentene carboxylic acid is acylated with a carboxylic acid halide to prepare a 4-acylamino-2-cyclopentene carboxylic acid derivative and the second stage wherein the acylamino-2-cyclopentene carboxylic acid derivative is reduced. In the formula, R1is 1-4C alkyl, etc. COPYRIGHT: (C)2010,JPO&INPIT