MONOCLONAL ANTIBODY SELECTIVE FOR HUMAN NEURAL STEM CELL AND SCREENING METHOD USING THE SAME

PROBLEM TO BE SOLVED: To provide a new antibody having high selectivity for a surface antigen of human neural stem cells, and a method for identifying and isolating a neural stem cell and/or a neural precursor cell and a highly Nestin-expressive cell, by an immunological method using the same. SOLUT...

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Hauptverfasser:	YAMAMOTO MUNEHIKO, NAKAMURA YASUHIRO, YAMAMOTO ATSUYO, YAMADA TOMIKO, ODA ERIKO, KANEMURA BEIHAKU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new antibody having high selectivity for a surface antigen of human neural stem cells, and a method for identifying and isolating a neural stem cell and/or a neural precursor cell and a highly Nestin-expressive cell, by an immunological method using the same. SOLUTION: The monoclonal antibody produced by the hybridoma of a myeloma with an antibody-producing cell of a mammal immunized by using a cultured human neurosphere homogenate is a new antibody (HFB184 antibody) highly selective for neural stem cells obtained by a screening result using a human brain tissue. The antibody selectively reacts to the surface antigen expressed by undifferentiated neural stem cells and disappearing during a differentiation process. COPYRIGHT: (C)2010,JPO&INPIT