METHOD FOR PRODUCING 13C-LABELED BENZENE AND 13C-LABELED BENZENE DERIVATIVE

PROBLEM TO BE SOLVED: To establish a method for synthesizing a13C-labeled aromatic compound such as13C-labeled benzene from13CH4or13CO2concentrated at a different content rate of a carbon stable isomer from a naturally existing rate as a starting raw material, and further to provide a13C-labeled benzene derivative. SOLUTION: This method for producing [13C6]-benzene includes a process for trimerizing [13C2]-acetylene in the presence of a metal catalyst and/or a zeolite catalyst. The [13C2]-acetylene may be produced by performing a non-equilibrium discharge in [13C]-methane, or by reacting13CO2with metal lithium to produce Li213C2and then reacting Li213C2with water to produce the [13C2]-acetylene. The13CO2is obtained by burning [13C]-methane in an oxygen atmosphere. Provided also are a method for producing a 1,2,3,4,5,10-[13C6]-estradiol compound from the [13C6]-benzene, and a [13C6]-benzene derivative. COPYRIGHT: (C)2009,JPO&INPIT