8-SUBSTITUTED GUANOSINE DERIVATIVE HAVING HYDROGEN-BONDING SUBSTITUENT AND OLIGONUCLEOTIDE CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide an 8-substituted guanosine derivative having a functional substituent at the 8-position of guanine and to provide an oligonucleotide containing the derivative. SOLUTION: A method for synthesizing the 8-substituted guanosine derivative comprises a series of (1) bromin...

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Hauptverfasser:	HANAWA KAZUO, MATSUMOTO YOSHIHIKO, SAITO RETSU, SAITO YOSHIO
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR ARTIFICIAL STONE CEMENTS CERAMICS CHEMISTRY COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDINGMATERIALS CONCRETE DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY LIME, MAGNESIA METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY REFRACTORIES SLAG SUGARS TREATMENT OF NATURAL STONE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an 8-substituted guanosine derivative having a functional substituent at the 8-position of guanine and to provide an oligonucleotide containing the derivative. SOLUTION: A method for synthesizing the 8-substituted guanosine derivative comprises a series of (1) bromination, (2) a coupling reaction of an alkylene compound using a Pd catalyst and (3) a catalytic hydrogenation step of a saccharide part under conditions of no protected hydroxy group using natural 2'-deoxyguanosine and guanosine as starting materials. COPYRIGHT: (C)2008,JPO&INPIT