HISTONE DEACETYLASE-RELATED GENE AND PROTEIN

PROBLEM TO BE SOLVED: To provide a histone deacetylase gene and a gene product, in particular, a protein that is highly homologous to known yeast histone deacetylase 1 (hda1) class II histone deacetylases (HDACs), nucleic acid molecules that encode such a protein, antibodies that recognize the prote...

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Bibliographische Detailangaben
Hauptverfasser:	BHATIA UMESH, COHEN DALIA, CAI RICHARD LIE, FISCHER DENISE DAWN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a histone deacetylase gene and a gene product, in particular, a protein that is highly homologous to known yeast histone deacetylase 1 (hda1) class II histone deacetylases (HDACs), nucleic acid molecules that encode such a protein, antibodies that recognize the protein, and methods for diagnosing conditions related to abnormal HDAC, including, for example, abnormal cell proliferation, cancer, atherosclerosis, inflammatory bowel disease, host-inflammatory or immune response or psoriasis. SOLUTION: The invention provides a nucleotide encoding a new HDAC9 polypeptide and an isolated polypeptide containing a specific amino acid sequence of the HDAC9 polypeptide. COPYRIGHT: (C)2008,JPO&INPIT