POLYSULFONE-BASED HOLLOW FIBER MEMBRANE TYPE BLOOD PURIFIER
PROBLEM TO BE SOLVED: To provide a blood purifier adapted as an HDFIII-b type blood purifier presented as a guideline by Japanese Society for Dialysis Therapy, which is a dry type. SOLUTION: For the polysulfone-based hollow fiber membrane type blood purifier, while cow blood adjusted to hematocrit (...
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| creator | MABUCHI KOYO KATO NORIAKI ONO HITOSHI KUZE KATSURO |
| description | PROBLEM TO BE SOLVED: To provide a blood purifier adapted as an HDFIII-b type blood purifier presented as a guideline by Japanese Society for Dialysis Therapy, which is a dry type. SOLUTION: For the polysulfone-based hollow fiber membrane type blood purifier, while cow blood adjusted to hematocrit (Ht) 40±2.0% and total protein concentration 6.5±0.5 g/dl is made to flow at 300 ml/min and at a filtration speed 90 ml/min to the blood purifier (inner diameter reference membrane area 1.5 m2) filled with polysulfone-based permselective hollow fiber membrane bundle containing polyvinylpyrroliidone, when sieving coefficients of β2-microglobulin after 15 minutes and after 120 minutes after starting hemofiltration are respectively defined as SCβ2MG (15 minutes) and SCβ2MG (120 minutes), it is SCβ2MG (120 minutes)/SCβ2MG (15 minutes)≥0.6. When the hollow fiber membrane bundle is divided into 10 pieces in a longitudinal direction and when a test determined by standards of approval for the manufacture of hemodialysis apparatuses is performed for respective parts, the hydrogen peroxide elution amount of obtained extract is ≤5 ppm in all the parts. COPYRIGHT: (C)2007,JPO&INPIT |
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SOLUTION: For the polysulfone-based hollow fiber membrane type blood purifier, while cow blood adjusted to hematocrit (Ht) 40±2.0% and total protein concentration 6.5±0.5 g/dl is made to flow at 300 ml/min and at a filtration speed 90 ml/min to the blood purifier (inner diameter reference membrane area 1.5 m2) filled with polysulfone-based permselective hollow fiber membrane bundle containing polyvinylpyrroliidone, when sieving coefficients of β2-microglobulin after 15 minutes and after 120 minutes after starting hemofiltration are respectively defined as SCβ2MG (15 minutes) and SCβ2MG (120 minutes), it is SCβ2MG (120 minutes)/SCβ2MG (15 minutes)≥0.6. When the hollow fiber membrane bundle is divided into 10 pieces in a longitudinal direction and when a test determined by standards of approval for the manufacture of hemodialysis apparatuses is performed for respective parts, the hydrogen peroxide elution amount of obtained extract is ≤5 ppm in all the parts. 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| subjects | APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE NATURAL OR ARTIFICIAL THREADS OR FIBRES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION SPINNING TEXTILES TRANSPORTING |
| title | POLYSULFONE-BASED HOLLOW FIBER MEMBRANE TYPE BLOOD PURIFIER |
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