NEW CARBAPENEM DERIVATIVE
PROBLEM TO BE SOLVED: To provide a carbapenem derivative which has a potent antimicrobial effect on pneumococci including MRSA, VRE and PRSP, influenza viruses including BLNAR and β-lactamase-producing strains from among resistant strains bringing about clinical problems. SOLUTION: The carbapenem de...
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| creator | ATSUMI KUNIO KURAZONO MIZUYO TADAUCHI KAORI AIHARA KAZUHIRO KANO YUUKO |
| description | PROBLEM TO BE SOLVED: To provide a carbapenem derivative which has a potent antimicrobial effect on pneumococci including MRSA, VRE and PRSP, influenza viruses including BLNAR and β-lactamase-producing strains from among resistant strains bringing about clinical problems. SOLUTION: The carbapenem derivative is represented by formula (I) and broadly has a potent antimicrobial effect on Gram-positive bacteria and Gram-negative bacteria. This carbapenem derivative has a potent antimicrobial effect on all sorts of pathogenic strains comprising particularly pneumococci including MRSA, VRE and PRSP, influenza viruses including BLNAR and β-lactamase-producing strains, and the compound of formula (I) is useful as not only an injection but also its ester derivative is useful as oral medicine. Furthermore, this carbapenem derivative has low toxicity and high safety. COPYRIGHT: (C)2006,JPO&NCIPI |
| format | Patent |
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SOLUTION: The carbapenem derivative is represented by formula (I) and broadly has a potent antimicrobial effect on Gram-positive bacteria and Gram-negative bacteria. This carbapenem derivative has a potent antimicrobial effect on all sorts of pathogenic strains comprising particularly pneumococci including MRSA, VRE and PRSP, influenza viruses including BLNAR and β-lactamase-producing strains, and the compound of formula (I) is useful as not only an injection but also its ester derivative is useful as oral medicine. Furthermore, this carbapenem derivative has low toxicity and high safety. 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SOLUTION: The carbapenem derivative is represented by formula (I) and broadly has a potent antimicrobial effect on Gram-positive bacteria and Gram-negative bacteria. This carbapenem derivative has a potent antimicrobial effect on all sorts of pathogenic strains comprising particularly pneumococci including MRSA, VRE and PRSP, influenza viruses including BLNAR and β-lactamase-producing strains, and the compound of formula (I) is useful as not only an injection but also its ester derivative is useful as oral medicine. Furthermore, this carbapenem derivative has low toxicity and high safety. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NEW CARBAPENEM DERIVATIVE |
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