CORRELATION OF RATIO OF TP TO DPDmRNA EXPRESSION LEVEL IN COLORECTAL CANCER WITH DISEASE-FREE SURVIVAL RATIO IN 5-FU TREATED PATIENT

PROBLEM TO BE SOLVED: To provide a method for identifying a parameter indicative for susceptibility to 5-fluoro-uracil (5-FU) and/or a 5-FU analogue in all potential parameters suggested in the prior art, and for determining under what conditions the parameter provides the highest possible specifici...

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Hauptverfasser:	PORSTMANN BAERBEL, LASSMANN SILKE, WALTER THOMAS, KRAUSE FRIEDMANN, POIGNEE MANUELA, WERNER MARTIN, LUTZ VERENA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for identifying a parameter indicative for susceptibility to 5-fluoro-uracil (5-FU) and/or a 5-FU analogue in all potential parameters suggested in the prior art, and for determining under what conditions the parameter provides the highest possible specificity. SOLUTION: The method for determining whether a patient suffering from cancer is susceptible to a treatment with the 5-FU and/or the 5-FU analogue comprises (a) determination of tymidine phosphorylase (TP) mRA expression in a clinical sample, (b) determination of diphydropyrimidine dehydrogenase (DPD) mRNA expression in the clinical sample, (c) determination of the ratio of the value obtained in step (a) to the value obtained in step (b), and (d) whether the ratio obtained in step (c) exceeds a predetermined cut off value. COPYRIGHT: (C)2005,JPO&NCIPI