SOMATOSTATIN ANALOG DERIVATIVE AND USE THEREOF

SOMATOSTATIN ANALOG DERIVATIVE AND USE THEREOF

PROBLEM TO BE SOLVED: To obtain a medicine composition for treatment and diagnosis that has low kidney accumulation, is safe, has high precision and is obtained by using a metal. SOLUTION: The carrier substance represented by formula (I) (R is a chelator residue; X is a phenyl group or a naphthyl gr...

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Hauptverfasser: ARANO YASUSHI, MIFUNE MASAKI, TAKIMOTO YAMATO, SAITO HIROSHI, SAJI HIDEO, MUKAI TAKAHIRO, AKISAWA HIROYUKI, IWATO AKIMASA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain a medicine composition for treatment and diagnosis that has low kidney accumulation, is safe, has high precision and is obtained by using a metal. SOLUTION: The carrier substance represented by formula (I) (R is a chelator residue; X is a phenyl group or a naphthyl group containing one or more free carboxy groups or amino groups; Y is a group selected from Thr-OH, Thr-NH2and Trp-NH2; A is Phe or Tyr; B is Thr or Val) is used for delivering a metal for diagnosis and/or treatment to a target cell expressing a somatostatin-bonding receptor. COPYRIGHT: (C)2005,JPO&NCIPI