INOSITOL DERIVATIVE, ITS PRODUCTION METHOD AND CYCLOOXYENASE-2 MANIFESTATION INHIBITOR

PROBLEM TO BE SOLVED: To synthesize a new compound using inositol which is a component of foods and industrially available in order to provide an effective and highly safe medicinal drug for inhibiting the manifestation of COX-2. SOLUTION: Inositol derivatives represented by formula (I) [wherein, R1...

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Hauptverfasser: IKEMOTO SHIGEAKI, WAKABAYASHI KEIJI, TANIGUCHI HISAJI, YAMANISHI HISAKO, KASHIWADA AYUMI, NAKAUCHI MICHIYO, HOSODA ASAO, OZAKI YOSHIHIKO, MUTO TSUNEHIRO
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creator IKEMOTO SHIGEAKI
WAKABAYASHI KEIJI
TANIGUCHI HISAJI
YAMANISHI HISAKO
KASHIWADA AYUMI
NAKAUCHI MICHIYO
HOSODA ASAO
OZAKI YOSHIHIKO
MUTO TSUNEHIRO
description PROBLEM TO BE SOLVED: To synthesize a new compound using inositol which is a component of foods and industrially available in order to provide an effective and highly safe medicinal drug for inhibiting the manifestation of COX-2. SOLUTION: Inositol derivatives represented by formula (I) [wherein, R1 is H or a substituent selected from the substituents represented by formula (II) (wherein, Me is methyl group), formula (III) and formula (IV) (wherein, Ac is acetyl group); R2 and R3 are each H or a substituent selected from the substituents represented by formula (III) and formula (IV)].
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title INOSITOL DERIVATIVE, ITS PRODUCTION METHOD AND CYCLOOXYENASE-2 MANIFESTATION INHIBITOR
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