5-AMINONICOTINIC ACID DERIVATIVE
PROBLEM TO BE SOLVED: To provide a new 5-aminonicotinic acid derivative having both fibrinogen receptor antagonism and vasodilator action, and to provide a medical composition containing the same. SOLUTION: The 5-aminonicotinic acid derivative represented by the general formula (I) (wherein, Q denot...
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| creator | RILL ATTILA BAARUTAANEE SARAI GISELA GIZUR TIBOR NOOGURAADEI KATALIN ADAM DEMETER KIS CHIRRA SCHON ISTVAN TOERLEY JOZSEF KYOTANI YOSHINORI YOKOYAMA TORU TRISCHLER FERENC NYEKI OLGA AGAINE CSONGOR EVA DOMANY GYOERGY GALAMBOS JANOS KASSAI FERENCNE |
| description | PROBLEM TO BE SOLVED: To provide a new 5-aminonicotinic acid derivative having both fibrinogen receptor antagonism and vasodilator action, and to provide a medical composition containing the same. SOLUTION: The 5-aminonicotinic acid derivative represented by the general formula (I) (wherein, Q denotes any group of five kinds e.g. formula (a); X denotes O or NCN group; Z denotes 2-nitroxyethyl, 2-methylpropyl, 1,1- dimethylpropyl, benzyl, 2-phenylethyl or 2-(2-chlorophenyl)ethyl group; R denotes H, an alkali metal atom, an alkaline earth metal atom or 1-4C alkyl group; the aspartic acid residue is racemic or optically active) and having both fibrinogen receptor antagonism and vasodilator action and, its pharmaceutically acceptable salt, solvate or hydrate, and a medical composition containing the compounds. The compound is especially useful as an inhibitor against platelet agglutination, platelet adhesiveness, and restenosis, a medicine for antiatheroselerotic arteriosclerosis, and a vasodilator for treating unstable stenocardia, cerebral apoplexy, cardiac infarction, and the like. |
| format | Patent |
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SOLUTION: The 5-aminonicotinic acid derivative represented by the general formula (I) (wherein, Q denotes any group of five kinds e.g. formula (a); X denotes O or NCN group; Z denotes 2-nitroxyethyl, 2-methylpropyl, 1,1- dimethylpropyl, benzyl, 2-phenylethyl or 2-(2-chlorophenyl)ethyl group; R denotes H, an alkali metal atom, an alkaline earth metal atom or 1-4C alkyl group; the aspartic acid residue is racemic or optically active) and having both fibrinogen receptor antagonism and vasodilator action and, its pharmaceutically acceptable salt, solvate or hydrate, and a medical composition containing the compounds. The compound is especially useful as an inhibitor against platelet agglutination, platelet adhesiveness, and restenosis, a medicine for antiatheroselerotic arteriosclerosis, and a vasodilator for treating unstable stenocardia, cerebral apoplexy, cardiac infarction, and the like.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020911&DB=EPODOC&CC=JP&NR=2002255939A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020911&DB=EPODOC&CC=JP&NR=2002255939A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RILL ATTILA</creatorcontrib><creatorcontrib>BAARUTAANEE SARAI GISELA</creatorcontrib><creatorcontrib>GIZUR TIBOR</creatorcontrib><creatorcontrib>NOOGURAADEI KATALIN</creatorcontrib><creatorcontrib>ADAM DEMETER</creatorcontrib><creatorcontrib>KIS CHIRRA</creatorcontrib><creatorcontrib>SCHON ISTVAN</creatorcontrib><creatorcontrib>TOERLEY JOZSEF</creatorcontrib><creatorcontrib>KYOTANI YOSHINORI</creatorcontrib><creatorcontrib>YOKOYAMA TORU</creatorcontrib><creatorcontrib>TRISCHLER FERENC</creatorcontrib><creatorcontrib>NYEKI OLGA</creatorcontrib><creatorcontrib>AGAINE CSONGOR EVA</creatorcontrib><creatorcontrib>DOMANY GYOERGY</creatorcontrib><creatorcontrib>GALAMBOS JANOS</creatorcontrib><creatorcontrib>KASSAI FERENCNE</creatorcontrib><title>5-AMINONICOTINIC ACID DERIVATIVE</title><description>PROBLEM TO BE SOLVED: To provide a new 5-aminonicotinic acid derivative having both fibrinogen receptor antagonism and vasodilator action, and to provide a medical composition containing the same. SOLUTION: The 5-aminonicotinic acid derivative represented by the general formula (I) (wherein, Q denotes any group of five kinds e.g. formula (a); X denotes O or NCN group; Z denotes 2-nitroxyethyl, 2-methylpropyl, 1,1- dimethylpropyl, benzyl, 2-phenylethyl or 2-(2-chlorophenyl)ethyl group; R denotes H, an alkali metal atom, an alkaline earth metal atom or 1-4C alkyl group; the aspartic acid residue is racemic or optically active) and having both fibrinogen receptor antagonism and vasodilator action and, its pharmaceutically acceptable salt, solvate or hydrate, and a medical composition containing the compounds. The compound is especially useful as an inhibitor against platelet agglutination, platelet adhesiveness, and restenosis, a medicine for antiatheroselerotic arteriosclerosis, and a vasodilator for treating unstable stenocardia, cerebral apoplexy, cardiac infarction, and the like.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAw1XX09fTz9_N09g_xBJIKjs6eLgourkGeYY4hnmGuPAysaYk5xam8UJqbQcnNNcTZQze1ID8-tbggMTk1L7Uk3ivAyMDAyMjU1NLY0tGYKEUAKFQiPw</recordid><startdate>20020911</startdate><enddate>20020911</enddate><creator>RILL ATTILA</creator><creator>BAARUTAANEE SARAI GISELA</creator><creator>GIZUR TIBOR</creator><creator>NOOGURAADEI KATALIN</creator><creator>ADAM DEMETER</creator><creator>KIS CHIRRA</creator><creator>SCHON ISTVAN</creator><creator>TOERLEY JOZSEF</creator><creator>KYOTANI YOSHINORI</creator><creator>YOKOYAMA TORU</creator><creator>TRISCHLER FERENC</creator><creator>NYEKI OLGA</creator><creator>AGAINE CSONGOR EVA</creator><creator>DOMANY GYOERGY</creator><creator>GALAMBOS JANOS</creator><creator>KASSAI FERENCNE</creator><scope>EVB</scope></search><sort><creationdate>20020911</creationdate><title>5-AMINONICOTINIC ACID DERIVATIVE</title><author>RILL ATTILA ; BAARUTAANEE SARAI GISELA ; GIZUR TIBOR ; NOOGURAADEI KATALIN ; ADAM DEMETER ; KIS CHIRRA ; SCHON ISTVAN ; TOERLEY JOZSEF ; KYOTANI YOSHINORI ; YOKOYAMA TORU ; TRISCHLER FERENC ; NYEKI OLGA ; AGAINE CSONGOR EVA ; DOMANY GYOERGY ; GALAMBOS JANOS ; KASSAI FERENCNE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2002255939A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RILL ATTILA</creatorcontrib><creatorcontrib>BAARUTAANEE SARAI GISELA</creatorcontrib><creatorcontrib>GIZUR TIBOR</creatorcontrib><creatorcontrib>NOOGURAADEI KATALIN</creatorcontrib><creatorcontrib>ADAM DEMETER</creatorcontrib><creatorcontrib>KIS CHIRRA</creatorcontrib><creatorcontrib>SCHON ISTVAN</creatorcontrib><creatorcontrib>TOERLEY JOZSEF</creatorcontrib><creatorcontrib>KYOTANI YOSHINORI</creatorcontrib><creatorcontrib>YOKOYAMA TORU</creatorcontrib><creatorcontrib>TRISCHLER FERENC</creatorcontrib><creatorcontrib>NYEKI OLGA</creatorcontrib><creatorcontrib>AGAINE CSONGOR EVA</creatorcontrib><creatorcontrib>DOMANY GYOERGY</creatorcontrib><creatorcontrib>GALAMBOS JANOS</creatorcontrib><creatorcontrib>KASSAI FERENCNE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RILL ATTILA</au><au>BAARUTAANEE SARAI GISELA</au><au>GIZUR TIBOR</au><au>NOOGURAADEI KATALIN</au><au>ADAM DEMETER</au><au>KIS CHIRRA</au><au>SCHON ISTVAN</au><au>TOERLEY JOZSEF</au><au>KYOTANI YOSHINORI</au><au>YOKOYAMA TORU</au><au>TRISCHLER FERENC</au><au>NYEKI OLGA</au><au>AGAINE CSONGOR EVA</au><au>DOMANY GYOERGY</au><au>GALAMBOS JANOS</au><au>KASSAI FERENCNE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-AMINONICOTINIC ACID DERIVATIVE</title><date>2002-09-11</date><risdate>2002</risdate><abstract>PROBLEM TO BE SOLVED: To provide a new 5-aminonicotinic acid derivative having both fibrinogen receptor antagonism and vasodilator action, and to provide a medical composition containing the same. SOLUTION: The 5-aminonicotinic acid derivative represented by the general formula (I) (wherein, Q denotes any group of five kinds e.g. formula (a); X denotes O or NCN group; Z denotes 2-nitroxyethyl, 2-methylpropyl, 1,1- dimethylpropyl, benzyl, 2-phenylethyl or 2-(2-chlorophenyl)ethyl group; R denotes H, an alkali metal atom, an alkaline earth metal atom or 1-4C alkyl group; the aspartic acid residue is racemic or optically active) and having both fibrinogen receptor antagonism and vasodilator action and, its pharmaceutically acceptable salt, solvate or hydrate, and a medical composition containing the compounds. The compound is especially useful as an inhibitor against platelet agglutination, platelet adhesiveness, and restenosis, a medicine for antiatheroselerotic arteriosclerosis, and a vasodilator for treating unstable stenocardia, cerebral apoplexy, cardiac infarction, and the like.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-AMINONICOTINIC ACID DERIVATIVE |
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