INACTIVATION OF VIRUS
PROBLEM TO BE SOLVED: To inactivate virus in a plasma protein solution by incubating the plasma protein solution at room temperature in an added state with a specific concentration of an ammonium salt, separating the precipitate, removing the ammonium salt, and by performing pasteurization to obtain...
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| creator | KUMPE GERHARDT NOWAK THOMAS SCHUELER ECKHARD |
| description | PROBLEM TO BE SOLVED: To inactivate virus in a plasma protein solution by incubating the plasma protein solution at room temperature in an added state with a specific concentration of an ammonium salt, separating the precipitate, removing the ammonium salt, and by performing pasteurization to obtain its pharmaceutical preparations. SOLUTION: By incubating a plasma protein solution, which is e.g. a plasma protein solution purified by affinity chromatography, at room temperature in an added state with an ammonium salt (e.g. ammonium sulfate, or the like) having 13-22 wt.% concentration, separating the precipitate, incubating the mixture again in a state that the ammonium concentration is increased up to 24-27 wt.%, removing the ammonium salt down to a residual content of |
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SOLUTION: By incubating a plasma protein solution, which is e.g. a plasma protein solution purified by affinity chromatography, at room temperature in an added state with an ammonium salt (e.g. ammonium sulfate, or the like) having 13-22 wt.% concentration, separating the precipitate, incubating the mixture again in a state that the ammonium concentration is increased up to 24-27 wt.%, removing the ammonium salt down to a residual content of <0.5 mol/L, by performing pasteurization at about 60 deg.C for a several hours e.g. in the presence of sucrose and glycine as stabilizers and then by making the solution into therapeutically usable plasma protein preparations, coated and/or noncoated virus(es) in the plasma protein solution is/are inactivated and/or removed in the added state with the ammonium salt at alkaline pH.</description><edition>7</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010109&DB=EPODOC&CC=JP&NR=2001000179A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010109&DB=EPODOC&CC=JP&NR=2001000179A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUMPE GERHARDT</creatorcontrib><creatorcontrib>NOWAK THOMAS</creatorcontrib><creatorcontrib>SCHUELER ECKHARD</creatorcontrib><title>INACTIVATION OF VIRUS</title><description>PROBLEM TO BE SOLVED: To inactivate virus in a plasma protein solution by incubating the plasma protein solution at room temperature in an added state with a specific concentration of an ammonium salt, separating the precipitate, removing the ammonium salt, and by performing pasteurization to obtain its pharmaceutical preparations. SOLUTION: By incubating a plasma protein solution, which is e.g. a plasma protein solution purified by affinity chromatography, at room temperature in an added state with an ammonium salt (e.g. ammonium sulfate, or the like) having 13-22 wt.% concentration, separating the precipitate, incubating the mixture again in a state that the ammonium concentration is increased up to 24-27 wt.%, removing the ammonium salt down to a residual content of <0.5 mol/L, by performing pasteurization at about 60 deg.C for a several hours e.g. in the presence of sucrose and glycine as stabilizers and then by making the solution into therapeutically usable plasma protein preparations, coated and/or noncoated virus(es) in the plasma protein solution is/are inactivated and/or removed in the added state with the ammonium salt at alkaline pH.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD19HN0DvEMcwzx9PdT8HdTCPMMCg3mYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBgaGBkBsbuloTJQiANmKH08</recordid><startdate>20010109</startdate><enddate>20010109</enddate><creator>KUMPE GERHARDT</creator><creator>NOWAK THOMAS</creator><creator>SCHUELER ECKHARD</creator><scope>EVB</scope></search><sort><creationdate>20010109</creationdate><title>INACTIVATION OF VIRUS</title><author>KUMPE GERHARDT ; NOWAK THOMAS ; SCHUELER ECKHARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2001000179A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2001</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KUMPE GERHARDT</creatorcontrib><creatorcontrib>NOWAK THOMAS</creatorcontrib><creatorcontrib>SCHUELER ECKHARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUMPE GERHARDT</au><au>NOWAK THOMAS</au><au>SCHUELER ECKHARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INACTIVATION OF VIRUS</title><date>2001-01-09</date><risdate>2001</risdate><abstract>PROBLEM TO BE SOLVED: To inactivate virus in a plasma protein solution by incubating the plasma protein solution at room temperature in an added state with a specific concentration of an ammonium salt, separating the precipitate, removing the ammonium salt, and by performing pasteurization to obtain its pharmaceutical preparations. SOLUTION: By incubating a plasma protein solution, which is e.g. a plasma protein solution purified by affinity chromatography, at room temperature in an added state with an ammonium salt (e.g. ammonium sulfate, or the like) having 13-22 wt.% concentration, separating the precipitate, incubating the mixture again in a state that the ammonium concentration is increased up to 24-27 wt.%, removing the ammonium salt down to a residual content of <0.5 mol/L, by performing pasteurization at about 60 deg.C for a several hours e.g. in the presence of sucrose and glycine as stabilizers and then by making the solution into therapeutically usable plasma protein preparations, coated and/or noncoated virus(es) in the plasma protein solution is/are inactivated and/or removed in the added state with the ammonium salt at alkaline pH.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INACTIVATION OF VIRUS |
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