PRODUCTION OF MONOCLONAL ANTIBODY
PROBLEM TO BE SOLVED: To increase the secretory capacity and produce the subject antibody by transducing an extraneous DNA capable of encoding the same amino acid sequence as that of a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin h...
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| creator | FUKUSHIMA ATSUSHI KUSUNOKI CHIHIRO |
| description | PROBLEM TO BE SOLVED: To increase the secretory capacity and produce the subject antibody by transducing an extraneous DNA capable of encoding the same amino acid sequence as that of a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and culturing the resultant transformed cell. SOLUTION: This method is to produce a monoclonal antibody and comprises transducing an extraneous DNA containing a gene capable of encoding an amino acid sequence of an immunoglobulin heavy chain polypeptide derived from a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and capable of secreting a monoclonal antibody comprising the immunoglobulin heavy chain polypeptide derived from the rearranged endogenous immunoglobulin heavy chain gene and an immunoglobulin light chain polypeptide derived from the rearranged endogenous immunoglobulin light chain gene, providing a transformed cell transformed with the extraneous DNA, culturing the resultant cell, obtaining the monoclonal antibody secreted into the cell culture fluid, thereby increasing the secretory capacity and affording the monoclonal antibody. |
| format | Patent |
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SOLUTION: This method is to produce a monoclonal antibody and comprises transducing an extraneous DNA containing a gene capable of encoding an amino acid sequence of an immunoglobulin heavy chain polypeptide derived from a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and capable of secreting a monoclonal antibody comprising the immunoglobulin heavy chain polypeptide derived from the rearranged endogenous immunoglobulin heavy chain gene and an immunoglobulin light chain polypeptide derived from the rearranged endogenous immunoglobulin light chain gene, providing a transformed cell transformed with the extraneous DNA, culturing the resultant cell, obtaining the monoclonal antibody secreted into the cell culture fluid, thereby increasing the secretory capacity and affording the monoclonal antibody.</description><edition>7</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001212&DB=EPODOC&CC=JP&NR=2000342279A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001212&DB=EPODOC&CC=JP&NR=2000342279A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUKUSHIMA ATSUSHI</creatorcontrib><creatorcontrib>KUSUNOKI CHIHIRO</creatorcontrib><title>PRODUCTION OF MONOCLONAL ANTIBODY</title><description>PROBLEM TO BE SOLVED: To increase the secretory capacity and produce the subject antibody by transducing an extraneous DNA capable of encoding the same amino acid sequence as that of a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and culturing the resultant transformed cell. SOLUTION: This method is to produce a monoclonal antibody and comprises transducing an extraneous DNA containing a gene capable of encoding an amino acid sequence of an immunoglobulin heavy chain polypeptide derived from a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and capable of secreting a monoclonal antibody comprising the immunoglobulin heavy chain polypeptide derived from the rearranged endogenous immunoglobulin heavy chain gene and an immunoglobulin light chain polypeptide derived from the rearranged endogenous immunoglobulin light chain gene, providing a transformed cell transformed with the extraneous DNA, culturing the resultant cell, obtaining the monoclonal antibody secreted into the cell culture fluid, thereby increasing the secretory capacity and affording the monoclonal antibody.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAMCPJ3CXUO8fT3U_B3U_D19_N39vH3c_RRcPQL8XTyd4nkYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBgYGxiZGRuaWjsZEKQIAalcivg</recordid><startdate>20001212</startdate><enddate>20001212</enddate><creator>FUKUSHIMA ATSUSHI</creator><creator>KUSUNOKI CHIHIRO</creator><scope>EVB</scope></search><sort><creationdate>20001212</creationdate><title>PRODUCTION OF MONOCLONAL ANTIBODY</title><author>FUKUSHIMA ATSUSHI ; KUSUNOKI CHIHIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2000342279A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2000</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FUKUSHIMA ATSUSHI</creatorcontrib><creatorcontrib>KUSUNOKI CHIHIRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FUKUSHIMA ATSUSHI</au><au>KUSUNOKI CHIHIRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION OF MONOCLONAL ANTIBODY</title><date>2000-12-12</date><risdate>2000</risdate><abstract>PROBLEM TO BE SOLVED: To increase the secretory capacity and produce the subject antibody by transducing an extraneous DNA capable of encoding the same amino acid sequence as that of a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and culturing the resultant transformed cell. SOLUTION: This method is to produce a monoclonal antibody and comprises transducing an extraneous DNA containing a gene capable of encoding an amino acid sequence of an immunoglobulin heavy chain polypeptide derived from a rearranged endogenous immunoglobulin heavy chain gene into a cell having the rearranged endogenous immunoglobulin heavy chain gene and a rearranged endogenous immunoglobulin light chain gene and capable of secreting a monoclonal antibody comprising the immunoglobulin heavy chain polypeptide derived from the rearranged endogenous immunoglobulin heavy chain gene and an immunoglobulin light chain polypeptide derived from the rearranged endogenous immunoglobulin light chain gene, providing a transformed cell transformed with the extraneous DNA, culturing the resultant cell, obtaining the monoclonal antibody secreted into the cell culture fluid, thereby increasing the secretory capacity and affording the monoclonal antibody.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | PRODUCTION OF MONOCLONAL ANTIBODY |
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