ANTIBACTERIAL OLIGOMER AND ANTIBACTERIAL AGENT
PROBLEM TO BE SOLVED: To obtain an oligomer having antibacterial action on bacteria, especially Gram-positive bacteria, above all such as vancomycin resistant Enterococcus and methicillin resistant Staphylococcus aureus by introducing a chemical structure of an antibiotic to a side chain of each rep...
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| creator | KAMIMURA DAISUKE YAZAWA KAZUYOSHI ARIMOTO HIROICHI YAMADA KAORU |
| description | PROBLEM TO BE SOLVED: To obtain an oligomer having antibacterial action on bacteria, especially Gram-positive bacteria, above all such as vancomycin resistant Enterococcus and methicillin resistant Staphylococcus aureus by introducing a chemical structure of an antibiotic to a side chain of each repeating unit and arranging the average degree of polymerization in a predetermined range. SOLUTION: This oligomer has a chemical structure of an antibiotic such as vancomycin, teicoplanin, ristocetin A or eremomycin, or the like, in each repeating unit, for example, expressed by the formula ((n) is an integer of 0-10; (m) is an integer of 2-60), has 2-30 of average degree of polymerization, and exhibits active antibacterial action on bacteria exhibiting resistance to the antibiotics. The formulating amount of the antibacterial oligomer in a pharmaceutical preparation is 0.2-10 wt.%, and preferably administered at a daily dose of 1-1,000 mg for an adult. |
| format | Patent |
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SOLUTION: This oligomer has a chemical structure of an antibiotic such as vancomycin, teicoplanin, ristocetin A or eremomycin, or the like, in each repeating unit, for example, expressed by the formula ((n) is an integer of 0-10; (m) is an integer of 2-60), has 2-30 of average degree of polymerization, and exhibits active antibacterial action on bacteria exhibiting resistance to the antibiotics. The formulating amount of the antibacterial oligomer in a pharmaceutical preparation is 0.2-10 wt.%, and preferably administered at a daily dose of 1-1,000 mg for an adult.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001031&DB=EPODOC&CC=JP&NR=2000302687A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001031&DB=EPODOC&CC=JP&NR=2000302687A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAMIMURA DAISUKE</creatorcontrib><creatorcontrib>YAZAWA KAZUYOSHI</creatorcontrib><creatorcontrib>ARIMOTO HIROICHI</creatorcontrib><creatorcontrib>YAMADA KAORU</creatorcontrib><title>ANTIBACTERIAL OLIGOMER AND ANTIBACTERIAL AGENT</title><description>PROBLEM TO BE SOLVED: To obtain an oligomer having antibacterial action on bacteria, especially Gram-positive bacteria, above all such as vancomycin resistant Enterococcus and methicillin resistant Staphylococcus aureus by introducing a chemical structure of an antibiotic to a side chain of each repeating unit and arranging the average degree of polymerization in a predetermined range. SOLUTION: This oligomer has a chemical structure of an antibiotic such as vancomycin, teicoplanin, ristocetin A or eremomycin, or the like, in each repeating unit, for example, expressed by the formula ((n) is an integer of 0-10; (m) is an integer of 2-60), has 2-30 of average degree of polymerization, and exhibits active antibacterial action on bacteria exhibiting resistance to the antibiotics. 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SOLUTION: This oligomer has a chemical structure of an antibiotic such as vancomycin, teicoplanin, ristocetin A or eremomycin, or the like, in each repeating unit, for example, expressed by the formula ((n) is an integer of 0-10; (m) is an integer of 2-60), has 2-30 of average degree of polymerization, and exhibits active antibacterial action on bacteria exhibiting resistance to the antibiotics. The formulating amount of the antibacterial oligomer in a pharmaceutical preparation is 0.2-10 wt.%, and preferably administered at a daily dose of 1-1,000 mg for an adult.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | ANTIBACTERIAL OLIGOMER AND ANTIBACTERIAL AGENT |
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