PRODUCTION OF 4-CHLOROBIPHENYL

PROBLEM TO BE SOLVED: To obtain 4-chlorobiphenyl in a high yield by reacting a haloaromatic compound with an aryl Grignard reagent in the presence of a palladium catalyst. SOLUTION: A compound of formula (R1a-R4al are each H, a 1-12C alkyl, a 2-12C alkenyl, CO-phenyl or the like; Halogen is Cl, Br o...

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Bibliographische Detailangaben
Hauptverfasser:	SCHERER STEFAN DR, MEUDT ANDREAS DR, HABER STEFFEN DR, NOERENBERG ANTJE DR
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain 4-chlorobiphenyl in a high yield by reacting a haloaromatic compound with an aryl Grignard reagent in the presence of a palladium catalyst. SOLUTION: A compound of formula (R1a-R4al are each H, a 1-12C alkyl, a 2-12C alkenyl, CO-phenyl or the like; Halogen is Cl, Br or I) is reacted with a compound of formula II (R5a to R9a are each H, a 1-12C alkyl, a 2-12C alkenyl, a 2-12C alkynyl or the like) in the presence of a palladium catalyst of formula III (R1 to R8 are each H, a 1-4C alkyl, a 5-8C cycloalkyl, a 1-4C alkoxy, F, NH2, phenyl or the like; R9 to R12 are each a 1-8C alkyl, a 5-8C cycloalkyl or an aryl; Y is an anion of an organic acid or inorganic acid) such as 1,1-bis(diphenylphosphino) ferrocene palladium (II) to give a compound of formula IV such as 4-chloro-2-methylbiphenyl, etc.