Modulator of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator
يتم الكشف عن مركبات لها الصيغة (I)، أملاح مقبولة صيدليًا منها، مشتقات معالجة بالديوتيريوم من أيٍ مما سبق، ونواتج أيض لأيٍ مما سبق. كما يتم الكشف عن تركيبات صيدلية تشتمل عليها، وطرق لعلاج التليف الكيسي باستخدامها، وطرق لتصنيعها. كما يتم الكشف عن صور في الحالة الصلبة للمركب 1 وأملاح وذوابات منه. Compo...
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| creator | PIERRE, Fabrice Jean, Denis GROSS, Raymond, Stanley KHATUYA, Haripada ABELA, Alexander, Russell MCCARTNEY, Jason CLEVELAND, Thomas KANG, Ping KESHAVARZ-SHOKRI, Ali JOSHI, Pramod, Virupax STAVROPOULOS, Kathy ALCACIO, Timothy FERRIS, Lori, Ann VAN GOOR, Fredrick, F TERMIN, Andreas, P BAEK, Minson SHI, Yi SHRESTHA, Muna GROOTENHUIS, Peter Diederik, Jan HSIA, Clara, Kuang-Ju ZHOU, Jinglan ANGELL, Paul, Timothy KRENITSKY, Paul, John MILLER, Mark, Thomas ANDERSON, Corey PARASELLI, Prasuna YOUNG, Tomothy, John GULEVICH, Anton UY, Johnny CLEMENS, Jeremy, J HADIDA RUAH, Sara, Sabina SIESEL, David, Andrew HUGHES, Robert, M |
| description | يتم الكشف عن مركبات لها الصيغة (I)، أملاح مقبولة صيدليًا منها، مشتقات معالجة بالديوتيريوم من أيٍ مما سبق، ونواتج أيض لأيٍ مما سبق. كما يتم الكشف عن تركيبات صيدلية تشتمل عليها، وطرق لعلاج التليف الكيسي باستخدامها، وطرق لتصنيعها. كما يتم الكشف عن صور في الحالة الصلبة للمركب 1 وأملاح وذوابات منه.
Compounds of Formula (I): (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof. |
| format | Patent |
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Compounds of Formula (I): (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.</description><language>ara ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220314&DB=EPODOC&CC=JO&NR=P20190125B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220314&DB=EPODOC&CC=JO&NR=P20190125B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PIERRE, Fabrice Jean, Denis</creatorcontrib><creatorcontrib>GROSS, Raymond, Stanley</creatorcontrib><creatorcontrib>KHATUYA, Haripada</creatorcontrib><creatorcontrib>ABELA, Alexander, Russell</creatorcontrib><creatorcontrib>MCCARTNEY, Jason</creatorcontrib><creatorcontrib>CLEVELAND, Thomas</creatorcontrib><creatorcontrib>KANG, Ping</creatorcontrib><creatorcontrib>KESHAVARZ-SHOKRI, Ali</creatorcontrib><creatorcontrib>JOSHI, Pramod, Virupax</creatorcontrib><creatorcontrib>STAVROPOULOS, Kathy</creatorcontrib><creatorcontrib>ALCACIO, Timothy</creatorcontrib><creatorcontrib>FERRIS, Lori, Ann</creatorcontrib><creatorcontrib>VAN GOOR, Fredrick, F</creatorcontrib><creatorcontrib>TERMIN, Andreas, P</creatorcontrib><creatorcontrib>BAEK, Minson</creatorcontrib><creatorcontrib>SHI, Yi</creatorcontrib><creatorcontrib>SHRESTHA, Muna</creatorcontrib><creatorcontrib>GROOTENHUIS, Peter Diederik, Jan</creatorcontrib><creatorcontrib>HSIA, Clara, Kuang-Ju</creatorcontrib><creatorcontrib>ZHOU, Jinglan</creatorcontrib><creatorcontrib>ANGELL, Paul, Timothy</creatorcontrib><creatorcontrib>KRENITSKY, Paul, John</creatorcontrib><creatorcontrib>MILLER, Mark, Thomas</creatorcontrib><creatorcontrib>ANDERSON, Corey</creatorcontrib><creatorcontrib>PARASELLI, Prasuna</creatorcontrib><creatorcontrib>YOUNG, Tomothy, John</creatorcontrib><creatorcontrib>GULEVICH, Anton</creatorcontrib><creatorcontrib>UY, Johnny</creatorcontrib><creatorcontrib>CLEMENS, Jeremy, J</creatorcontrib><creatorcontrib>HADIDA RUAH, Sara, Sabina</creatorcontrib><creatorcontrib>SIESEL, David, Andrew</creatorcontrib><creatorcontrib>HUGHES, Robert, M</creatorcontrib><title>Modulator of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator</title><description>يتم الكشف عن مركبات لها الصيغة (I)، أملاح مقبولة صيدليًا منها، مشتقات معالجة بالديوتيريوم من أيٍ مما سبق، ونواتج أيض لأيٍ مما سبق. كما يتم الكشف عن تركيبات صيدلية تشتمل عليها، وطرق لعلاج التليف الكيسي باستخدامها، وطرق لتصنيعها. كما يتم الكشف عن صور في الحالة الصلبة للمركب 1 وأملاح وذوابات منه.
Compounds of Formula (I): (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjrFqw0AQRNW4CLb_YXGtgKSQwq1FhAmIiKBerO9W1hHdrbhdFfmU_G3OOLhONc17M_OU_bRs1xmVI_AI9beoM9C4S2RxAn3EIJ78JSVBzcGuRjEYgk-63rUcugmjR0NrUnFOlF-SrI6D5NCSTmzlVt5HQvUUNAcMFrrIhkRgTNMtfrlwBZ0IHn922WbEWWj_l9vs0Lz19fmZFh5IlrQYSIf3j64qymNRVq-n8uVf0C9epFMY</recordid><startdate>20220314</startdate><enddate>20220314</enddate><creator>PIERRE, Fabrice Jean, Denis</creator><creator>GROSS, Raymond, Stanley</creator><creator>KHATUYA, Haripada</creator><creator>ABELA, Alexander, Russell</creator><creator>MCCARTNEY, Jason</creator><creator>CLEVELAND, Thomas</creator><creator>KANG, Ping</creator><creator>KESHAVARZ-SHOKRI, Ali</creator><creator>JOSHI, Pramod, Virupax</creator><creator>STAVROPOULOS, Kathy</creator><creator>ALCACIO, Timothy</creator><creator>FERRIS, Lori, Ann</creator><creator>VAN GOOR, Fredrick, F</creator><creator>TERMIN, Andreas, P</creator><creator>BAEK, Minson</creator><creator>SHI, Yi</creator><creator>SHRESTHA, Muna</creator><creator>GROOTENHUIS, Peter Diederik, Jan</creator><creator>HSIA, Clara, Kuang-Ju</creator><creator>ZHOU, Jinglan</creator><creator>ANGELL, Paul, Timothy</creator><creator>KRENITSKY, Paul, John</creator><creator>MILLER, Mark, Thomas</creator><creator>ANDERSON, Corey</creator><creator>PARASELLI, Prasuna</creator><creator>YOUNG, Tomothy, John</creator><creator>GULEVICH, Anton</creator><creator>UY, Johnny</creator><creator>CLEMENS, Jeremy, J</creator><creator>HADIDA RUAH, Sara, Sabina</creator><creator>SIESEL, David, Andrew</creator><creator>HUGHES, Robert, M</creator><scope>EVB</scope></search><sort><creationdate>20220314</creationdate><title>Modulator of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator</title><author>PIERRE, Fabrice Jean, Denis ; 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Compounds of Formula (I): (I), pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Modulator of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator |
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