Cyclohexylpyrazole-Lactam Derivatives as inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1
يقدم الاختراع الحالي مركب جديد من الصيغه I: له تاثير فسيولوجي ل 11 B- HSD type 1 وكذلك طريقة تحضيره، وفي تجسيد اخر يقدم الاختراع تركيبات صيدلانية تتضمن مركبات من الصيغه I وكذلك طريقة استخدامه ومكوناته لعلاج داء السكري وارتفاع نسبة السكر بالدم والسمنة وارتفاع ضغط الدم وارتفاع نسبة الدهون بالدم واعراض...
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| creator | Thomas Edward Mabry Hongqi Tian Leonard Larry Winneroski,Junior Owen Brendan Waalace Renhua Li Alexei Pavlovych Krasutsky Yanping Xu Peter Biagio Anzeveno Thomas Daniel Aicher Ashraf Saeed Gregory Alan Stephenson Nancy June Snyder |
| description | يقدم الاختراع الحالي مركب جديد من الصيغه I: له تاثير فسيولوجي ل 11 B- HSD type 1 وكذلك طريقة تحضيره، وفي تجسيد اخر يقدم الاختراع تركيبات صيدلانية تتضمن مركبات من الصيغه I وكذلك طريقة استخدامه ومكوناته لعلاج داء السكري وارتفاع نسبة السكر بالدم والسمنة وارتفاع ضغط الدم وارتفاع نسبة الدهون بالدم واعراض التمثيل الحيوي المضطرب، كما يعالج أي ظروف اخرى مصاحبة لنشاط 11 B- HSD type 1.
The present invention discloses novel compounds of formula i Having 11B-HSD type 1 antagonist activity, as well as methods for preparing such compounds, in another embodiment, the invention discloses pharmaceutical compositions comprising compounds of formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11B-HSD type 1 activity. |
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The present invention discloses novel compounds of formula i Having 11B-HSD type 1 antagonist activity, as well as methods for preparing such compounds, in another embodiment, the invention discloses pharmaceutical compositions comprising compounds of formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11B-HSD type 1 activity.</description><language>ara ; eng</language><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160905&DB=EPODOC&CC=JO&NR=3042B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160905&DB=EPODOC&CC=JO&NR=3042B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Thomas Edward Mabry</creatorcontrib><creatorcontrib>Hongqi Tian</creatorcontrib><creatorcontrib>Leonard Larry Winneroski,Junior</creatorcontrib><creatorcontrib>Owen Brendan Waalace</creatorcontrib><creatorcontrib>Renhua Li</creatorcontrib><creatorcontrib>Alexei Pavlovych Krasutsky</creatorcontrib><creatorcontrib>Yanping Xu</creatorcontrib><creatorcontrib>Peter Biagio Anzeveno</creatorcontrib><creatorcontrib>Thomas Daniel Aicher</creatorcontrib><creatorcontrib>Ashraf Saeed</creatorcontrib><creatorcontrib>Gregory Alan Stephenson</creatorcontrib><creatorcontrib>Nancy June Snyder</creatorcontrib><title>Cyclohexylpyrazole-Lactam Derivatives as inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1</title><description>يقدم الاختراع الحالي مركب جديد من الصيغه I: له تاثير فسيولوجي ل 11 B- HSD type 1 وكذلك طريقة تحضيره، وفي تجسيد اخر يقدم الاختراع تركيبات صيدلانية تتضمن مركبات من الصيغه I وكذلك طريقة استخدامه ومكوناته لعلاج داء السكري وارتفاع نسبة السكر بالدم والسمنة وارتفاع ضغط الدم وارتفاع نسبة الدهون بالدم واعراض التمثيل الحيوي المضطرب، كما يعالج أي ظروف اخرى مصاحبة لنشاط 11 B- HSD type 1.
The present invention discloses novel compounds of formula i Having 11B-HSD type 1 antagonist activity, as well as methods for preparing such compounds, in another embodiment, the invention discloses pharmaceutical compositions comprising compounds of formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11B-HSD type 1 activity.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi0EKwjAUBbtxIeoRhFwgYKwnaFWKCG7cSvm2ryYQ-0t-KI2nV8G9q4EZZp7dytR4tpiSH1KgF3voMzWRnmqP4EaKboQoEuV66-4uchDFnTJGF4ikq9QGnpJEBHbt57Ff8UBPAmWW2awjL1j9uMjWx8O1rDQGriEDNegR69Ml3-y2hcn_9TdPKzqh</recordid><startdate>20160905</startdate><enddate>20160905</enddate><creator>Thomas Edward Mabry</creator><creator>Hongqi Tian</creator><creator>Leonard Larry Winneroski,Junior</creator><creator>Owen Brendan Waalace</creator><creator>Renhua Li</creator><creator>Alexei Pavlovych Krasutsky</creator><creator>Yanping Xu</creator><creator>Peter Biagio Anzeveno</creator><creator>Thomas Daniel Aicher</creator><creator>Ashraf Saeed</creator><creator>Gregory Alan Stephenson</creator><creator>Nancy June Snyder</creator><scope>EVB</scope></search><sort><creationdate>20160905</creationdate><title>Cyclohexylpyrazole-Lactam Derivatives as inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1</title><author>Thomas Edward Mabry ; Hongqi Tian ; Leonard Larry Winneroski,Junior ; Owen Brendan Waalace ; Renhua Li ; Alexei Pavlovych Krasutsky ; Yanping Xu ; Peter Biagio Anzeveno ; Thomas Daniel Aicher ; Ashraf Saeed ; Gregory Alan Stephenson ; Nancy June Snyder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JO3042B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ara ; eng</language><creationdate>2016</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Thomas Edward Mabry</creatorcontrib><creatorcontrib>Hongqi Tian</creatorcontrib><creatorcontrib>Leonard Larry Winneroski,Junior</creatorcontrib><creatorcontrib>Owen Brendan Waalace</creatorcontrib><creatorcontrib>Renhua Li</creatorcontrib><creatorcontrib>Alexei Pavlovych Krasutsky</creatorcontrib><creatorcontrib>Yanping Xu</creatorcontrib><creatorcontrib>Peter Biagio Anzeveno</creatorcontrib><creatorcontrib>Thomas Daniel Aicher</creatorcontrib><creatorcontrib>Ashraf Saeed</creatorcontrib><creatorcontrib>Gregory Alan Stephenson</creatorcontrib><creatorcontrib>Nancy June Snyder</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Thomas Edward Mabry</au><au>Hongqi Tian</au><au>Leonard Larry Winneroski,Junior</au><au>Owen Brendan Waalace</au><au>Renhua Li</au><au>Alexei Pavlovych Krasutsky</au><au>Yanping Xu</au><au>Peter Biagio Anzeveno</au><au>Thomas Daniel Aicher</au><au>Ashraf Saeed</au><au>Gregory Alan Stephenson</au><au>Nancy June Snyder</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cyclohexylpyrazole-Lactam Derivatives as inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1</title><date>2016-09-05</date><risdate>2016</risdate><abstract>يقدم الاختراع الحالي مركب جديد من الصيغه I: له تاثير فسيولوجي ل 11 B- HSD type 1 وكذلك طريقة تحضيره، وفي تجسيد اخر يقدم الاختراع تركيبات صيدلانية تتضمن مركبات من الصيغه I وكذلك طريقة استخدامه ومكوناته لعلاج داء السكري وارتفاع نسبة السكر بالدم والسمنة وارتفاع ضغط الدم وارتفاع نسبة الدهون بالدم واعراض التمثيل الحيوي المضطرب، كما يعالج أي ظروف اخرى مصاحبة لنشاط 11 B- HSD type 1.
The present invention discloses novel compounds of formula i Having 11B-HSD type 1 antagonist activity, as well as methods for preparing such compounds, in another embodiment, the invention discloses pharmaceutical compositions comprising compounds of formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11B-HSD type 1 activity.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Cyclohexylpyrazole-Lactam Derivatives as inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 |
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