DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI
1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 5-Alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I) see diagramm : EP0185130,P26,F3 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lo...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | ita |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | PITRE' DAVIDE FELDER ERNST FUMAGALLI LUCIANO |
| description | 1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 5-Alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I) see diagramm : EP0185130,P26,F3 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P27,F1 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line. 1. Claims (for the Contracting State AT) Process for the preparation of 5-alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I). see diagramm : EP0185130,P28,F1 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P28,F2 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line, cha |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_IT8423965A0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>IT8423965A0</sourcerecordid><originalsourceid>FETCH-epo_espacenet_IT8423965A03</originalsourceid><addsrcrecordid>eNqNjTEKwkAQRdNYiHqH6WyyIDGKluPuRAfWTJgsFmlCkLUSFfQcntkVPIDVf_AfvHH2dqR8wsDgyPs5WnYCK4PeStuyKfIyX5ugzOLEgMCXdypHMdxKFdCzlRyOFNIPDSl4BC-aWKlBxY6lJiBQ8ily4qR2XYoxWKmDYhsEFB2Llz1bnmajy3B9xtlvJxlUFOzBxMe9j8_HcI63-Oo5bMpiuV2vcLH8Q_kAskY-9g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI</title><source>esp@cenet</source><creator>PITRE' DAVIDE ; FELDER ERNST ; FUMAGALLI LUCIANO</creator><creatorcontrib>PITRE' DAVIDE ; FELDER ERNST ; FUMAGALLI LUCIANO</creatorcontrib><description>1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 5-Alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I) see diagramm : EP0185130,P26,F3 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P27,F1 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line. 1. Claims (for the Contracting State AT) Process for the preparation of 5-alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I). see diagramm : EP0185130,P28,F1 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P28,F2 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line, characterized in that a compound of the general formula II see diagramm : EP0185130,P28,F3 in which X, R'1 , R'2 , R'3 and R'4 have the abovementioned meaning for X, R1 , R2 , R3 and R4 , but free hydroxyl groups present in the molecule may also be present in protected form, or an alkali metal salt or alkaline-earth metal salt thereof, is reacted, in a manner which is known per se, with a compound of the general formula III R'5 -Z in which Z denotes a reactive halogen atom CI, Br or iodine, or a reactive sulphonic acid radical, and R'5 has the abovementioned meaning for R5 or represents an alkoxycarbonyl alkyl group having 3 to 8 C atoms, and, in the resultant compound of the formula IV see diagramm : EP0185130,P29,F1 in which the various symbols have the abovementioned meaning, 5-alkoxycarbonylalkoxy groups present are converted into the corresponding 5-aminocarbonylalkoxy group through reaction with a primary and secondary amine, and finally, protecting groups masking hydroxyl functins are removed by hydrolysis and the compound of the formula I is isolated.</description><edition>3</edition><language>ita</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19841210&DB=EPODOC&CC=IT&NR=8423965A0$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19841210&DB=EPODOC&CC=IT&NR=8423965A0$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PITRE' DAVIDE</creatorcontrib><creatorcontrib>FELDER ERNST</creatorcontrib><creatorcontrib>FUMAGALLI LUCIANO</creatorcontrib><title>DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI</title><description>1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 5-Alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I) see diagramm : EP0185130,P26,F3 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P27,F1 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line. 1. Claims (for the Contracting State AT) Process for the preparation of 5-alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I). see diagramm : EP0185130,P28,F1 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P28,F2 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line, characterized in that a compound of the general formula II see diagramm : EP0185130,P28,F3 in which X, R'1 , R'2 , R'3 and R'4 have the abovementioned meaning for X, R1 , R2 , R3 and R4 , but free hydroxyl groups present in the molecule may also be present in protected form, or an alkali metal salt or alkaline-earth metal salt thereof, is reacted, in a manner which is known per se, with a compound of the general formula III R'5 -Z in which Z denotes a reactive halogen atom CI, Br or iodine, or a reactive sulphonic acid radical, and R'5 has the abovementioned meaning for R5 or represents an alkoxycarbonyl alkyl group having 3 to 8 C atoms, and, in the resultant compound of the formula IV see diagramm : EP0185130,P29,F1 in which the various symbols have the abovementioned meaning, 5-alkoxycarbonylalkoxy groups present are converted into the corresponding 5-aminocarbonylalkoxy group through reaction with a primary and secondary amine, and finally, protecting groups masking hydroxyl functins are removed by hydrolysis and the compound of the formula I is isolated.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjTEKwkAQRdNYiHqH6WyyIDGKluPuRAfWTJgsFmlCkLUSFfQcntkVPIDVf_AfvHH2dqR8wsDgyPs5WnYCK4PeStuyKfIyX5ugzOLEgMCXdypHMdxKFdCzlRyOFNIPDSl4BC-aWKlBxY6lJiBQ8ily4qR2XYoxWKmDYhsEFB2Llz1bnmajy3B9xtlvJxlUFOzBxMe9j8_HcI63-Oo5bMpiuV2vcLH8Q_kAskY-9g</recordid><startdate>19841210</startdate><enddate>19841210</enddate><creator>PITRE' DAVIDE</creator><creator>FELDER ERNST</creator><creator>FUMAGALLI LUCIANO</creator><scope>EVB</scope></search><sort><creationdate>19841210</creationdate><title>DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI</title><author>PITRE' DAVIDE ; FELDER ERNST ; FUMAGALLI LUCIANO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IT8423965A03</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ita</language><creationdate>1984</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>PITRE' DAVIDE</creatorcontrib><creatorcontrib>FELDER ERNST</creatorcontrib><creatorcontrib>FUMAGALLI LUCIANO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PITRE' DAVIDE</au><au>FELDER ERNST</au><au>FUMAGALLI LUCIANO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI</title><date>1984-12-10</date><risdate>1984</risdate><abstract>1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) 5-Alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I) see diagramm : EP0185130,P26,F3 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P27,F1 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line. 1. Claims (for the Contracting State AT) Process for the preparation of 5-alkoxy-2,4,6-triiodo- or tribromo-isophthalic diamides of the general formula (I). see diagramm : EP0185130,P28,F1 in which X denotes iodine or bromine R1 and R3 may be identical or different, namely denote hydrogen, lower alkyl or hydroxyalkyl, R2 and R4 may be identical or different, namely denote hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, R5 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, denotes (poly) alkoxyalkyl having 1 to 10 oxa functions and 3 to 33 C atoms, denotes hydroxy(poly) alkyl having 1 to 10 oxa functions and 4 to 33 C atoms denotes aminocarbonylalkyl of the formula see diagramm : EP0185130,P28,F2 in which R6 denotes H, alkyl or hydroxyalkyl, R7 denotes hydroxyalkyl having 1 to 5 HO functions and 2 to 6 C atoms, and alkylene denotes straight-chain or branched divalent alkylene having 1 to 5 C atoms, and R5 denotes alkyl having 10 to 20 C atoms, or A-alkylene'-, in which alkylene' denotes divalent alkylene having 2 to 12 C atoms and 0 to 5 oxa, thia, HO or amide functions, and A denotes a 3,5-bis-(aminocarbonyl)-2,4,6-trihalo-phenoxy radical of the formula I, which is located within the dashed line, characterized in that a compound of the general formula II see diagramm : EP0185130,P28,F3 in which X, R'1 , R'2 , R'3 and R'4 have the abovementioned meaning for X, R1 , R2 , R3 and R4 , but free hydroxyl groups present in the molecule may also be present in protected form, or an alkali metal salt or alkaline-earth metal salt thereof, is reacted, in a manner which is known per se, with a compound of the general formula III R'5 -Z in which Z denotes a reactive halogen atom CI, Br or iodine, or a reactive sulphonic acid radical, and R'5 has the abovementioned meaning for R5 or represents an alkoxycarbonyl alkyl group having 3 to 8 C atoms, and, in the resultant compound of the formula IV see diagramm : EP0185130,P29,F1 in which the various symbols have the abovementioned meaning, 5-alkoxycarbonylalkoxy groups present are converted into the corresponding 5-aminocarbonylalkoxy group through reaction with a primary and secondary amine, and finally, protecting groups masking hydroxyl functins are removed by hydrolysis and the compound of the formula I is isolated.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | ita |
| recordid | cdi_epo_espacenet_IT8423965A0 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | DERIVATI DELL'ACIDO 5-ALCOSSI-2,4,6-TRIIODO- O -TRIBROMO-ISOFTALICO, METODO PER LA LORO PREPARAZIONE E RELATIVI MEZZI DI CONTRASTO RADIOLOGICI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T12%3A24%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PITRE'%20DAVIDE&rft.date=1984-12-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EIT8423965A0%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |