PROCEDIMENTO PER LA IMMOBILIZZAZIONE CHIMICA DI SOSTANZE BIOLOGICAMENTE ATTIVE SU SILICE

A process is disclosed for the chemical immobilization of biologically active substances having a proteinic structure on SiO2 supports, which comprises preparing a support of SiO2 functionalised with organic silanes complying with the following general formula wherein: R1 and R2, either equal to, or different from, each other, are Cl, Br, CH3, NO2, H or NH2, R, R and R, either equal to, or different from, one another, are alkyl or alkoxy groups containing from 1 to 10 carbon atoms, R is equal to (CH2)p-X-(CH2)q, wherein X is CH2 or a mono- or poly-condensed aromatic group, or NH or O, p and q, either equal to, or different from, each other, are integers which can have values comprised within the range of from 0 to 10, with the value of 0 being excluded when X is either NH or O, and coupling the silica functionalised with the organic silane with a biologically active substance having a proteinic structure, after previously preparing a diazo salt on such a functionalised silica.