DERIVATI DI 7-OSSO-4-TIA-1-AZA-BICICLO-[3,2,0]EPTANO
This invention relates to 7-oxo-4-thia-1-aza-bicyclo-[3,2,0]-heptane derivatives, to processes for their synthesis from esters of penicillanic acid 1-oxide, and to intermediate compounds obtained in the synthesis. More particularly, the present invention relates to new and novel compounds of formula...
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| creator | FOGLIO MAURIZIO ARCAMONE FEDERICO SCARAFILE COSIMO FRANCESCHI GIOVANNI |
| description | This invention relates to 7-oxo-4-thia-1-aza-bicyclo-[3,2,0]-heptane derivatives, to processes for their synthesis from esters of penicillanic acid 1-oxide, and to intermediate compounds obtained in the synthesis. More particularly, the present invention relates to new and novel compounds of formula (1): (1) wherein R is a hydrogen atom, an alkyl having from 1 to 5 carbon atoms, trichloroethyl, benzyl, p-nitrobenzyl, diphenylmethyl, acetoxymethyl, pivaloyloxymethyl, phthalidyl, trimethylsilyl or a group of formula and R1 is -CH2OH, -CH2OCOR2, -CH2OR3, -COOR2, -CHO, -CH2SH, -CH2SR4, -CH2NH2, -CH2NHCOR2 in which R2 is an alkyl having from 1 to 5 carbon atoms, aryl, aralkyl or a five- or six-membered heterocyclic ring containing one or more heteroatoms; R3 is an alkyl having from 1 to 5 carbon atoms, benzyl, trityl, trialkylsilyl; and R4 is a five- or six-membered heterocyclic ring containing one or more heteroatoms, benzyl, trityl or trialkylsilyl; and to the synthesis of such compounds. Compounds of formula (1) (E+Z isomers) are endowed with antibacterial activity. |
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More particularly, the present invention relates to new and novel compounds of formula (1): (1) wherein R is a hydrogen atom, an alkyl having from 1 to 5 carbon atoms, trichloroethyl, benzyl, p-nitrobenzyl, diphenylmethyl, acetoxymethyl, pivaloyloxymethyl, phthalidyl, trimethylsilyl or a group of formula and R1 is -CH2OH, -CH2OCOR2, -CH2OR3, -COOR2, -CHO, -CH2SH, -CH2SR4, -CH2NH2, -CH2NHCOR2 in which R2 is an alkyl having from 1 to 5 carbon atoms, aryl, aralkyl or a five- or six-membered heterocyclic ring containing one or more heteroatoms; R3 is an alkyl having from 1 to 5 carbon atoms, benzyl, trityl, trialkylsilyl; and R4 is a five- or six-membered heterocyclic ring containing one or more heteroatoms, benzyl, trityl or trialkylsilyl; and to the synthesis of such compounds. 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More particularly, the present invention relates to new and novel compounds of formula (1): (1) wherein R is a hydrogen atom, an alkyl having from 1 to 5 carbon atoms, trichloroethyl, benzyl, p-nitrobenzyl, diphenylmethyl, acetoxymethyl, pivaloyloxymethyl, phthalidyl, trimethylsilyl or a group of formula and R1 is -CH2OH, -CH2OCOR2, -CH2OR3, -COOR2, -CHO, -CH2SH, -CH2SR4, -CH2NH2, -CH2NHCOR2 in which R2 is an alkyl having from 1 to 5 carbon atoms, aryl, aralkyl or a five- or six-membered heterocyclic ring containing one or more heteroatoms; R3 is an alkyl having from 1 to 5 carbon atoms, benzyl, trityl, trialkylsilyl; and R4 is a five- or six-membered heterocyclic ring containing one or more heteroatoms, benzyl, trityl or trialkylsilyl; and to the synthesis of such compounds. 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More particularly, the present invention relates to new and novel compounds of formula (1): (1) wherein R is a hydrogen atom, an alkyl having from 1 to 5 carbon atoms, trichloroethyl, benzyl, p-nitrobenzyl, diphenylmethyl, acetoxymethyl, pivaloyloxymethyl, phthalidyl, trimethylsilyl or a group of formula and R1 is -CH2OH, -CH2OCOR2, -CH2OR3, -COOR2, -CHO, -CH2SH, -CH2SR4, -CH2NH2, -CH2NHCOR2 in which R2 is an alkyl having from 1 to 5 carbon atoms, aryl, aralkyl or a five- or six-membered heterocyclic ring containing one or more heteroatoms; R3 is an alkyl having from 1 to 5 carbon atoms, benzyl, trityl, trialkylsilyl; and R4 is a five- or six-membered heterocyclic ring containing one or more heteroatoms, benzyl, trityl or trialkylsilyl; and to the synthesis of such compounds. Compounds of formula (1) (E+Z isomers) are endowed with antibacterial activity.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVATI DI 7-OSSO-4-TIA-1-AZA-BICICLO-[3,2,0]EPTANO |
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