GLUCOSIDI ANTRACICLINONICI
Anthracycline glycosides of the formula I I wherein R is hydrogen or hydroxy, one of R1 and R2 is methyl and the other of R1 and R2 is hydroxy, and pharmaceutically acceptable acid addition salts thereof, which are useful in treating certain mammalian tumors, are prepared by condensing daunomycinone...
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| creator | BARGIOTTI ALBERTO CASSINELLI GIUSEPPE PENCO SERGIO ARCAMONE FEDERICO DI MARCO AURELIO |
| description | Anthracycline glycosides of the formula I I wherein R is hydrogen or hydroxy, one of R1 and R2 is methyl and the other of R1 and R2 is hydroxy, and pharmaceutically acceptable acid addition salts thereof, which are useful in treating certain mammalian tumors, are prepared by condensing daunomycinone with certain novel sugars in an inert organic solvent and in the presence of a soluble silver salt and a dehydrating agent to form the corresponding protected glycosides from which the protecting groups are removed. This gives the compounds wherein R is hydrogen. The former are converted to the corresponding hydroxyl compounds by treatment with bromine and sodium formate. |
| format | Patent |
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This gives the compounds wherein R is hydrogen. The former are converted to the corresponding hydroxyl compounds by treatment with bromine and sodium formate.</description><edition>4</edition><language>ita</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890202&DB=EPODOC&CC=IT&NR=1201937B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890202&DB=EPODOC&CC=IT&NR=1201937B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARGIOTTI ALBERTO</creatorcontrib><creatorcontrib>CASSINELLI GIUSEPPE</creatorcontrib><creatorcontrib>PENCO SERGIO</creatorcontrib><creatorcontrib>ARCAMONE FEDERICO</creatorcontrib><creatorcontrib>DI MARCO AURELIO</creatorcontrib><title>GLUCOSIDI ANTRACICLINONICI</title><description>Anthracycline glycosides of the formula I I wherein R is hydrogen or hydroxy, one of R1 and R2 is methyl and the other of R1 and R2 is hydroxy, and pharmaceutically acceptable acid addition salts thereof, which are useful in treating certain mammalian tumors, are prepared by condensing daunomycinone with certain novel sugars in an inert organic solvent and in the presence of a soluble silver salt and a dehydrating agent to form the corresponding protected glycosides from which the protecting groups are removed. This gives the compounds wherein R is hydrogen. The former are converted to the corresponding hydroxyl compounds by treatment with bromine and sodium formate.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBy9wl19g_2dPFUcPQLCXJ09nT28fTz9_N09uRhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfGeIYZGBoaWxuZOxoRVAADGYh-i</recordid><startdate>19890202</startdate><enddate>19890202</enddate><creator>BARGIOTTI ALBERTO</creator><creator>CASSINELLI GIUSEPPE</creator><creator>PENCO SERGIO</creator><creator>ARCAMONE FEDERICO</creator><creator>DI MARCO AURELIO</creator><scope>EVB</scope></search><sort><creationdate>19890202</creationdate><title>GLUCOSIDI ANTRACICLINONICI</title><author>BARGIOTTI ALBERTO ; CASSINELLI GIUSEPPE ; PENCO SERGIO ; ARCAMONE FEDERICO ; DI MARCO AURELIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IT1201937B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ita</language><creationdate>1989</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>BARGIOTTI ALBERTO</creatorcontrib><creatorcontrib>CASSINELLI GIUSEPPE</creatorcontrib><creatorcontrib>PENCO SERGIO</creatorcontrib><creatorcontrib>ARCAMONE FEDERICO</creatorcontrib><creatorcontrib>DI MARCO AURELIO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARGIOTTI ALBERTO</au><au>CASSINELLI GIUSEPPE</au><au>PENCO SERGIO</au><au>ARCAMONE FEDERICO</au><au>DI MARCO AURELIO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>GLUCOSIDI ANTRACICLINONICI</title><date>1989-02-02</date><risdate>1989</risdate><abstract>Anthracycline glycosides of the formula I I wherein R is hydrogen or hydroxy, one of R1 and R2 is methyl and the other of R1 and R2 is hydroxy, and pharmaceutically acceptable acid addition salts thereof, which are useful in treating certain mammalian tumors, are prepared by condensing daunomycinone with certain novel sugars in an inert organic solvent and in the presence of a soluble silver salt and a dehydrating agent to form the corresponding protected glycosides from which the protecting groups are removed. This gives the compounds wherein R is hydrogen. The former are converted to the corresponding hydroxyl compounds by treatment with bromine and sodium formate.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| language | ita |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | GLUCOSIDI ANTRACICLINONICI |
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