CEFALOSPORINE-BETAINE DI ISOCHINOLINIO

Broad spectrum cephalosporin betaine antibiotics represented by the formula wherein R' is a heterocyclic ring, e.g. 2-aminothiazol-4-yl, 2-amino-1,3,5-thiadiazol-4-yl, or 2-aminopyridin-6-yl; R'' is C1-C4 alkyl, especially methyl, a substituted carbamoyl group, or a carboxy-substitute...

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Bibliographische Detailangaben
Hauptverfasser:	SHADLE JOHN KEVIN, LUNN WILLIAM HENRY WALKER
Format:	Patent
Sprache:	ita
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Broad spectrum cephalosporin betaine antibiotics represented by the formula wherein R' is a heterocyclic ring, e.g. 2-aminothiazol-4-yl, 2-amino-1,3,5-thiadiazol-4-yl, or 2-aminopyridin-6-yl; R'' is C1-C4 alkyl, especially methyl, a substituted carbamoyl group, or a carboxy-substituted alkyl or cycloalkyl group; and R1 is isoquinolinium or a substituted isoquinolinium group are provided. Compounds wherein R1 is isoquinolinium are preferred especially syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(isoquinolin ium-2-ylmethyl)-3-cephem-4-carboxylate. Pharmaceutical formulations and a method for treating infectious diseases comprising the use of the antibiotics are described.