Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylt...
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| creator | PER JOHAN LUTHMAN ROBERT SCHWARCZ SUSANNA KARIN MARIA BJOERK KERSTIN MARGARETA IRMA PERSSON KRISTINA BIRGITTA GOTTHAMMAR MATS TORBJOERN LINDERBERG |
| description | The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN. |
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SUSANNA KARIN MARIA BJOERK ; KERSTIN MARGARETA IRMA PERSSON ; KRISTINA BIRGITTA GOTTHAMMAR ; MATS TORBJOERN LINDERBERG</creatorcontrib><description>The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><edition>5</edition><language>ice</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; 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X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZCh2PLwhLbXo8AaFskwgkVaUmJuTCmQV55QqHF6okHd4b1ZprkJiGlgQzFIw1s04vDelKL_i8N7EvJKixLzMnMzs4sN7i0oV8tMVcjNzcjJT0_IysRm4LzWzqCiRh4E1LTGnOJUXSnMzyLi5hjh76KYW5MenFhckJqfmpZbEewabGBqbOBoTkAYArj9Lng</recordid><startdate>19940827</startdate><enddate>19940827</enddate><creator>PER JOHAN LUTHMAN</creator><creator>ROBERT SCHWARCZ</creator><creator>SUSANNA KARIN MARIA BJOERK</creator><creator>KERSTIN MARGARETA IRMA PERSSON</creator><creator>KRISTINA BIRGITTA GOTTHAMMAR</creator><creator>MATS TORBJOERN LINDERBERG</creator><scope>EVB</scope></search><sort><creationdate>19940827</creationdate><title>Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra</title><author>PER JOHAN LUTHMAN ; ROBERT SCHWARCZ ; SUSANNA KARIN MARIA BJOERK ; KERSTIN MARGARETA IRMA PERSSON ; KRISTINA BIRGITTA GOTTHAMMAR ; MATS TORBJOERN LINDERBERG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IS4134A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ice</language><creationdate>1994</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PER JOHAN LUTHMAN</creatorcontrib><creatorcontrib>ROBERT SCHWARCZ</creatorcontrib><creatorcontrib>SUSANNA KARIN MARIA BJOERK</creatorcontrib><creatorcontrib>KERSTIN MARGARETA IRMA PERSSON</creatorcontrib><creatorcontrib>KRISTINA BIRGITTA GOTTHAMMAR</creatorcontrib><creatorcontrib>MATS TORBJOERN LINDERBERG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PER JOHAN LUTHMAN</au><au>ROBERT SCHWARCZ</au><au>SUSANNA KARIN MARIA BJOERK</au><au>KERSTIN MARGARETA IRMA PERSSON</au><au>KRISTINA BIRGITTA GOTTHAMMAR</au><au>MATS TORBJOERN LINDERBERG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra</title><date>1994-08-27</date><risdate>1994</risdate><abstract>The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I I wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula I wherein R1 and R2=H, X=Br and Y=Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra |
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