SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	SHIPPS, GERALD, W. JR, GIBEAU, CRAIG, R, SEIDEL-DUGAN, CYNTHIA, LIU, YUAN, PAN, WEIDONG, VOSS, MATTHEW ERNST, SCAPIN, GIOVANNA, RINDGEN, DIANE, TIAN, YUAN, MACCOSS, MALCOLM, BOGEN, STEPHANE, L, GUZI, TIMOTHY, J, LAHUE, BRIAN ROBERT, SHIZUKA, MANAMI, NOMEIR, AMIN, MA, YAO, NAIR, LATHA, G, WANG, YAOLIN, HICKLIN, DANNY, J, DOLL, RONALD, J, KIROVA-SNOVER, MARGARITA, KULKARNI, BHEEMASHANKAR, A
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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