An improved process for the preparation of fidaxomicin

An improved process for the preparation of fidaxomicin

Abstract AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L br...

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Hauptverfasser: PATEL MITESH JAGDISHKUMAR, MEHTA DHIMANT PUNJALAL, PATEL JAYESH CHANDUBHAI, VAID ANKUR SUDHIR, DHIMAN ANAND MAHADEV
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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creator PATEL MITESH JAGDISHKUMAR
MEHTA DHIMANT PUNJALAL
PATEL JAYESH CHANDUBHAI
VAID ANKUR SUDHIR
DHIMAN ANAND MAHADEV
description Abstract AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.
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subjects CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
title An improved process for the preparation of fidaxomicin
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