An improved process for the preparation of fidaxomicin

Abstract AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L br...

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Bibliographische Detailangaben
Hauptverfasser:	PATEL MITESH JAGDISHKUMAR, MEHTA DHIMANT PUNJALAL, PATEL JAYESH CHANDUBHAI, VAID ANKUR SUDHIR, DHIMAN ANAND MAHADEV
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS
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Beschreibung
Zusammenfassung:	Abstract AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.