FENOFIBRATE FORMULATION
Various fenofibrate dosage forms contain a plurality of beads or particles where the beads or particles include a pharmaceutical composition comprising fenofibrate; from 0.3% to 10% by weight of the beads or particles of a surfactant; and from about 5% to about 15% by weight of the beads or particle...
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creator | SHAW ANDREW ALAN CHATTARAJ SARAT C REDELMAN GLENN ALLEN |
description | Various fenofibrate dosage forms contain a plurality of beads or particles where the beads or particles include a pharmaceutical composition comprising fenofibrate; from 0.3% to 10% by weight of the beads or particles of a surfactant; and from about 5% to about 15% by weight of the beads or particles of a water soluble or water dispersible cellulosic binder. The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1; and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1. |
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The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1; and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150925&DB=EPODOC&CC=IN&NR=11040DEN2014A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150925&DB=EPODOC&CC=IN&NR=11040DEN2014A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHAW ANDREW ALAN</creatorcontrib><creatorcontrib>CHATTARAJ SARAT C</creatorcontrib><creatorcontrib>REDELMAN GLENN ALLEN</creatorcontrib><title>FENOFIBRATE FORMULATION</title><description>Various fenofibrate dosage forms contain a plurality of beads or particles where the beads or particles include a pharmaceutical composition comprising fenofibrate; from 0.3% to 10% by weight of the beads or particles of a surfactant; and from about 5% to about 15% by weight of the beads or particles of a water soluble or water dispersible cellulosic binder. The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1; and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB3c_Xzd_N0CnIMcVVw8w_yDfVxDPH09-NhYE1LzClO5YXS3Axqbq4hzh66qQX58anFBYnJqXmpJfGefoaGBiYGLq4-fgFGBoYmjsZEKwQAM1oiaQ</recordid><startdate>20150925</startdate><enddate>20150925</enddate><creator>SHAW ANDREW ALAN</creator><creator>CHATTARAJ SARAT C</creator><creator>REDELMAN GLENN ALLEN</creator><scope>EVB</scope></search><sort><creationdate>20150925</creationdate><title>FENOFIBRATE FORMULATION</title><author>SHAW ANDREW ALAN ; CHATTARAJ SARAT C ; REDELMAN GLENN ALLEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IN11040DELNP2014A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>SHAW ANDREW ALAN</creatorcontrib><creatorcontrib>CHATTARAJ SARAT C</creatorcontrib><creatorcontrib>REDELMAN GLENN ALLEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHAW ANDREW ALAN</au><au>CHATTARAJ SARAT C</au><au>REDELMAN GLENN ALLEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FENOFIBRATE FORMULATION</title><date>2015-09-25</date><risdate>2015</risdate><abstract>Various fenofibrate dosage forms contain a plurality of beads or particles where the beads or particles include a pharmaceutical composition comprising fenofibrate; from 0.3% to 10% by weight of the beads or particles of a surfactant; and from about 5% to about 15% by weight of the beads or particles of a water soluble or water dispersible cellulosic binder. The mass ratio of the drug to the binder in the dosage form is between about 3.5:1 and 4.5:1; and the dosage form produces a first Cmax in vivo that is between about 10% and about 50% higher than a comparative Cmax produced by a comparative dosage form. The comparative dosage form comprises the drug and the binder in a ratio of between about 5:1 and 15:1.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
title | FENOFIBRATE FORMULATION |
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