Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
Described herein are methods of modulating OTC gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for increasing expression of Ornithine transcarbamylase (OTC), thereby treating diseases a...
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| creator | KELKAR Rachana S BUMCROT David A SEHGAL Alfica AKERBERG Brynn Nicole-Yoshiko GAMBOA Mario Esteban Contreras ROY Subhadeep MATTHEWS Bryan J CARAVELLA Justin A JUNG Yun Joon LIU Yuting SMITH Cynthia M PAI Rutuja Sudhakar |
| description | Described herein are methods of modulating OTC gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for increasing expression of Ornithine transcarbamylase (OTC), thereby treating diseases associated with aberrant gene expression. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas |
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