Macrocyclic chelates and uses thereof

The present disclosure relates to macrocyclic chelates including a macrocyclic chelating moiety of a metal complex thereof, a bifunctional linker, and a therapeutic or targeting moiety. Also disclosed are methods for preparation of the same, and use thereof.

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Hauptverfasser: CHASSE Melissa, BURAK Eric S, MORAN Matthew D, SIMMS Ryan W, JOHANSEN Michael B, VALLIANT John F, MAHONEY Stuart James
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Sprache:eng ; heb
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creator CHASSE Melissa
BURAK Eric S
MORAN Matthew D
SIMMS Ryan W
JOHANSEN Michael B
VALLIANT John F
MAHONEY Stuart James
description The present disclosure relates to macrocyclic chelates including a macrocyclic chelating moiety of a metal complex thereof, a bifunctional linker, and a therapeutic or targeting moiety. Also disclosed are methods for preparation of the same, and use thereof.
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language eng ; heb
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subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Macrocyclic chelates and uses thereof
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