Process for the preparation of cortexolone 17α-propionate and new hydrated crystalline form thereof

The present invention is directed to a process for the preparation of cortexolone 17α-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III)in which R is a hydrogen atom or a methyl group,in the presence of a dilute solution of acetic acid.The present invention is also direc...

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Bibliographische Detailangaben
Hauptverfasser:	Ponzinibi Matteo, Roberto Arosio, Di Giacomo Mario, Brusasca Marco
Format:	Patent
Sprache:	eng ; heb
Schlagworte:	ADHESIVES CHEMISTRY DYES LAKES METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS MORDANTS NATURAL RESINS ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES PAINTS POLISHES
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Beschreibung
Zusammenfassung:	The present invention is directed to a process for the preparation of cortexolone 17α-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III)in which R is a hydrogen atom or a methyl group,in the presence of a dilute solution of acetic acid.The present invention is also directed to a hydrated crystalline form of cortexolone 17a-propionate obtained by such process.