Tetrazines for high click release speed and yield

Tetrazines for high click release speed and yield

Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield and high click release yields. In some of several other aspects, the invention relates to combinations and kits having the tetrazines and a dienophile, preferably a trans-cyclooctene. In another asp...

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Hauptverfasser: HOEBEN Freek Johannes Maria, ROBILLARD Marc Stefan, VERSTEEGEN Ronny Mathieu, ROSSIN Raffaella, JANSSEN Henricus Marie
Format: Patent
Sprache:eng ; heb
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creator HOEBEN Freek Johannes Maria
ROBILLARD Marc Stefan
VERSTEEGEN Ronny Mathieu
ROSSIN Raffaella
JANSSEN Henricus Marie
description Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield and high click release yields. In some of several other aspects, the invention relates to combinations and kits having the tetrazines and a dienophile, preferably a trans-cyclooctene. In another aspect, the compounds, combinations, and kits are for use as a medicament.
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title Tetrazines for high click release speed and yield
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